日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Total Syntheses of Stereoisomeric Congeners of Rufomycin Natural Products Having Anti-Mycobacterial Activity

具有抗分枝杆菌活性的鲁福霉素天然产物立体异构体的全合成

Fei, Fan; Lun, Shichun; Pacheco, Alexander; Bishai, William R; Sello, Jason K

Total Syntheses of Cyclomarin and Metamarin Natural Products

环马林和间马林天然产物的全合成

Fei, Fan; Lun, Shichun; Saxena, Aditi; Raghavan, Madhura; DeRisi, Joseph L; Bishai, William R; Sello, Jason K

Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro

酰基缩肽类抗生素及其生物活性片段在体外对结核分枝杆菌ClpXP1P2活性产生差异性干扰

Schmitz, Karl R; Handy, Emma L; Compton, Corey L; Gupta, Shashank; Bishai, William R; Sauer, Robert T; Sello, Jason K

Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge

富含羟基且不带正电荷的亲水性内吞促进肽

Wang, Siwen; Li, Zhonghan; Aispuro, Desiree; Guevara, Nathan; Van Valkenburgh, Juno; Chen, Boxi; Zhou, Xiaoyun; McCarroll, Matthew N; Ji, Fei; Cong, Xu; Sarkar, Priyanka; Chaudhuri, Rohit; Guo, Zhili; Perkins, Nicole P; Shao, Shiqun; Sello, Jason K; Chen, Kai; Xue, Min

A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor

一种特殊的 IclR 家族转录因子调控链霉菌(Streptomyces coelicolor)中的对羟基苯甲酸分解代谢。

Zhang, Rui; Lord, Dana M; Bajaj, Rakhi; Peti, Wolfgang; Page, Rebecca; Sello, Jason K

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle

高度动态的相互作用维持着ClpXP蛋白酶在ATP驱动的机械循环中的动力学稳定性。

Amor, Alvaro J; Schmitz, Karl R; Sello, Jason K; Baker, Tania A; Sauer, Robert T

A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus

构象受限的环状酰基缩肽对感染甲氧西林敏感和耐药金黄色葡萄球菌的小鼠均具有高效性

Arvanitis, Marios; Li, Gang; Li, De-Dong; Cotnoir, Daniel; Ganley-Leal, Lisa; Carney, Daniel W; Sello, Jason K; Mylonakis, Eleftherios

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines

底物导向的丁香酚优化可获得对白血病细胞系具有活性的强效蛋白酶体抑制剂。

Totaro, Kyle A; Barthelme, Dominik; Simpson, Peter T; Sauer, Robert T; Sello, Jason K

Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase

环状酰基缩肽类抗生素与ClpP肽酶相互作用的肽模拟结构模型研究

Carney, Daniel W; Schmitz, Karl R; Scruse, Anthony C; Sauer, Robert T; Sello, Jason K

Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses

对一种逆向运输抑制剂进行结构优化,该抑制剂可保护细胞免受人类多瘤病毒和乳头瘤病毒的感染

Carney, Daniel W; Nelson, Christian D S; Ferris, Bennett D; Stevens, Julia P; Lipovsky, Alex; Kazakov, Teymur; DiMaio, Daniel; Atwood, Walter J; Sello, Jason K