日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief

这并非你母亲那一代的激素疗法:高选择性雌激素受体β激动剂作为缓解更年期症状的新一代疗法

Frick, Karyn M; Fleischer, Aaron W; Schwabe, Miranda R; Abdelazim, Farah A; Sem, Daniel S; Donaldson, William A

Structural and kinetic characterization of DUSP5 with a Di-phosphorylated tripeptide substrate from the ERK activation loop

利用来自ERK激活环的二磷酸化三肽底物对DUSP5进行结构和动力学表征

Imhoff, Andrea; Sweeney, Noreena L; Bongard, Robert D; Syrlybaeva, Raulia; Gupta, Ankan; Del Carpio, Edgar; Talipov, Marat R; Garcia-Keller, Costanza; Crans, Debbie C; Ramchandran, Ramani; Sem, Daniel S

Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice

长期口服一种新型雌激素受体β激动剂可增强年轻卵巢切除小鼠的记忆力并减轻药物引起的血管舒张。

Fleischer, Aaron W; Schalk, Jayson C; Wetzel, Edward A; Hanson, Alicia M; Sem, Daniel S; Donaldson, William A; Frick, Karyn M

Discovery and Characterization of Halogenated Xanthene Inhibitors of DUSP5 as Potential Photodynamic Therapeutics.

发现和表征DUSP5卤代呫吨抑制剂作为潜在的光动力疗法

Bongard Robert D, Lepley Michael, Gastonguay Adam, Syrlybaeva Raulia R, Talipov Marat R, Lipinsky Rachel A Jones, Leigh Noah R, Brahmbhatt Jaladhi, Kutty Raman, Rathore Rajendra, Ramchandran Ramani, Sem Daniel S

Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus

与结核分枝杆菌硫氧还蛋白还原酶蛋白对接,可获得用于耐甲氧西林金黄色葡萄球菌的吡唑酮类先导化合物

Sweeney, Noreena L; Lipker, Lauren; Hanson, Alicia M; Bohl, Chris J; Engel, Katie E; Kalous, Kelsey S; Stemper, Mary E; Sem, Daniel S; Schwan, William R

Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2

内源性大麻素转运蛋白:研究甾醇载体蛋白-2的工具发现

Hillard, Cecilia J; Huang, Huan; Vogt, Caleb D; Rodrigues, Beatriz E; Neumann, Terrence S; Sem, Daniel S; Schroeder, Friedhelm; Cunningham, Christopher W

Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.

偶然发现光诱导(原位)形成偶氮桥联二聚磺化萘酚是一种有效的 PTP1B 抑制剂

Bongard Robert D, Lepley Michael, Thakur Khushabu, Talipov Marat R, Nayak Jaladhi, Lipinski Rachel A Jones, Bohl Chris, Sweeney Noreena, Ramchandran Ramani, Rathore Rajendra, Sem Daniel S

A Novel Scoring Based Distributed Protein Docking Application to Improve Enrichment

一种基于评分的新型分布式蛋白质对接应用程序,用于提高富集效果

Pradeep, Prachi; Struble, Craig; Neumann, Terrence; Sem, Daniel S; Merrill, Stephen J

Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design

结核分枝杆菌硫氧还蛋白C的溶液结构和完整硫氧还蛋白系统的模型为抑制剂和药物设计提供了新的思路。

Olson, Andrew L; Neumann, Terrence S; Cai, Sheng; Sem, Daniel S

Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase

利用分子对接和核磁共振结合研究鉴定人磷酸甲羟戊酸激酶的新型抑制剂

Boonsri, Pornthip; Neumann, Terrence S; Olson, Andrew L; Cai, Sheng; Herdendorf, Timothy J; Miziorko, Henry M; Hannongbua, Supa; Sem, Daniel S