日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.

针对副作用较小的 1 型大麻素受体激动剂的虚拟库对接

Tummino Tia A, Iliopoulos-Tsoutsouvas Christos, Braz Joao M, O'Brien Evan S, Stein Reed M, Craik Veronica, Tran Ngan K, Ganapathy Suthakar, Liu Fangyu, Shiimura Yuki, Tong Fei, Ho Thanh C, Radchenko Dmytro S, Moroz Yurii S, Rosado Sian Rodriguez, Bhardwaj Karnika, Benitez Jorge, Liu Yongfeng, Kandasamy Herthana, Normand Claire, Semache Meriem, Sabbagh Laurent, Glenn Isabella, Irwin John J, Kumar Kaavya Krishna, Makriyannis Alexandros, Basbaum Allan I, Shoichet Brian K

Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity

慢性 UCN2 治疗可降低 CRHR2 的敏感性并改善胰岛素敏感性

Stephen E Flaherty 3rd #, Olivier Bezy #, Wei Zheng, Dong Yan, Xiangping Li, Srinath Jagarlapudi, Bina Albuquerque, Ryan M Esquejo, Matthew Peloquin, Meriem Semache, Arturo Mancini, Liya Kang, Doreen Drujan, Susanne B Breitkopf, John D Griffin, Pierre M Jean Beltran, Liang Xue, John Stansfield, Evan

Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome

多巴胺能和血清素能神经传递的机制见解 - 与螺旋 5 和 6 的协同相互作用推动功能结果

Tomasz Maciej Stepniewski, Arturo Mancini, Richard Ågren, Mariona Torrens-Fontanals, Meriem Semache, Michel Bouvier, Kristoffer Sahlholm, Billy Breton, Jana Selent

Ackr3-Venus knock-in mouse lights up brain vasculature

Ackr3-Venus 基因敲入小鼠激活脑血管

Aliza T Ehrlich, Meriem Semache #, Pierre Couvineau #, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L Kieffer

The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects

PAR2 抑制剂 I-287 选择性靶向 Gαq 和 Gα12/13 信号,具有抗炎作用

Charlotte Avet, Claudio Sturino, Sébastien Grastilleur, Christian Le Gouill, Meriem Semache, Florence Gross, Louis Gendron, Youssef Bennani, Joseph A Mancini, Camil E Sayegh, Michel Bouvier

Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons

天然神经元中μ阿片受体的偏向性信号传导揭示

Ehrlich, Aliza T; Semache, Meriem; Gross, Florence; Da Fonte, Dillon F; Runtz, Leonie; Colley, Christine; Mezni, Amina; Le Gouill, Christian; Lukasheva, Viktoriya; Hogue, Mireille; Darcq, Emmanuel; Bouvier, Michel; Kieffer, Brigitte L

Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing

绘制 GPR88-Venus 地图阐明了 GPR88 在感官处理中的新作用

Aliza T Ehrlich, Meriem Semache, Julie Bailly, Stefan Wojcik, Tanzil M Arefin, Christine Colley, Christian Le Gouill, Florence Gross, Viktoriya Lukasheva, Mireille Hogue, Emmanuel Darcq, Laura-Adela Harsan, Michel Bouvier, Brigitte L Kieffer

Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells

Per-Arnt-Sim 激酶通过胰腺 β 细胞中糖原合酶激酶 3β 的磷酸化来调节胰腺十二指肠同源框-1 蛋白的稳定性

Meriem Semache, Bader Zarrouki, Ghislaine Fontés, Sarah Fogarty, Chintan Kikani, Mohammad B Chawki, Jared Rutter, Vincent Poitout

Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

脂多糖通过 Toll 样受体 4 和 NF-κB 信号通路抑制分离的胰岛中胰岛素基因的表达

Amyot, Julie; Semache, Meriem; Ferdaoussi, Mourad; Fontés, Ghislaine; Poitout, Vincent

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

人类 Per-Arnt-Sim (PAS) 结构域蛋白激酶 (PASK) 的突变会导致基础胰岛素分泌过多

Semplici Francesca, Vaxillaire Martine, Fogarty Sarah, Semache Meriem, Bonnefond Amélie, Fontés Ghislaine, Philippe Julien, Meur Gargi, Diraison Frederique, Sessions Richard B, Rutter Jared, Poitout Vincent, Froguel Philippe, Rutter Guy A