日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.

针对副作用较小的 1 型大麻素受体激动剂的虚拟库对接

Tummino Tia A, Iliopoulos-Tsoutsouvas Christos, Braz Joao M, O'Brien Evan S, Stein Reed M, Craik Veronica, Tran Ngan K, Ganapathy Suthakar, Liu Fangyu, Shiimura Yuki, Tong Fei, Ho Thanh C, Radchenko Dmytro S, Moroz Yurii S, Rosado Sian Rodriguez, Bhardwaj Karnika, Benitez Jorge, Liu Yongfeng, Kandasamy Herthana, Normand Claire, Semache Meriem, Sabbagh Laurent, Glenn Isabella, Irwin John J, Kumar Kaavya Krishna, Makriyannis Alexandros, Basbaum Allan I, Shoichet Brian K

Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons

天然神经元中μ阿片受体的偏向性信号传导揭示

Ehrlich, Aliza T; Semache, Meriem; Gross, Florence; Da Fonte, Dillon F; Runtz, Leonie; Colley, Christine; Mezni, Amina; Le Gouill, Christian; Lukasheva, Viktoriya; Hogue, Mireille; Darcq, Emmanuel; Bouvier, Michel; Kieffer, Brigitte L

Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

脂多糖通过 Toll 样受体 4 和 NF-κB 信号通路抑制分离的胰岛中胰岛素基因的表达

Amyot, Julie; Semache, Meriem; Ferdaoussi, Mourad; Fontés, Ghislaine; Poitout, Vincent

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

人类 Per-Arnt-Sim (PAS) 结构域蛋白激酶 (PASK) 的突变会导致基础胰岛素分泌过多

Semplici Francesca, Vaxillaire Martine, Fogarty Sarah, Semache Meriem, Bonnefond Amélie, Fontés Ghislaine, Philippe Julien, Meur Gargi, Diraison Frederique, Sessions Richard B, Rutter Jared, Poitout Vincent, Froguel Philippe, Rutter Guy A

Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity

在体内糖脂毒性模型中,胰高血糖素样肽-1激动剂或二肽基肽酶-4抑制剂均未能保护胰岛素基因表达。

Fontés, Ghislaine; Hagman, Derek K; Latour, Martin G; Semache, Meriem; Poitout, Vincent

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells

Per-Arnt-Sim激酶和细胞外调节激酶-1/2参与棕榈酸酯对胰岛β细胞胰岛素基因表达的抑制作用

Fontés, Ghislaine; Semache, Meriem; Hagman, Derek K; Tremblay, Caroline; Shah, Ramila; Rhodes, Christopher J; Rutter, Jared; Poitout, Vincent

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding

脂肪酸受体GPR40在体内高脂饮食后的胰岛素分泌中发挥作用。

Kebede, Melkam; Alquier, Thierry; Latour, Martin G; Semache, Meriem; Tremblay, Caroline; Poitout, Vincent

Peroxisome proliferator-activated receptor gamma 1 expression is diminished in human osteoarthritis cartilage and is downregulated by IL-1β in articular chondrocytes

过氧化物酶体增殖激活受体γ1在人类骨关节炎软骨中的表达降低,并且在关节软骨细胞中受IL-1β下调。

Hagman, Derek K; Latour, Martin G; Chakrabarti, Swarup K; Fontes, Ghislaine; Amyot, Julie; Tremblay, Caroline; Semache, Meriem; Lausier, James A; Roskens, Violet; Mirmira, Raghavendra G; Jetton, Thomas L; Poitout, Vincent; Afif, H; Mfuna, L; Martel-Pelletier, J; Pelletier, J-P; Fahmi, H