The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse
新型 γ 分泌酶抑制剂 N-[顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己基]-1,1,1-三氟甲磺酰胺 (MRK-560) 可减少 Tg2576 小鼠中的淀粉样斑块沉积，且无缺口相关病理证据
期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.1
doi:10.1124/jpet.106.114330
Jonathan D Best, David W Smith, Michael A Reilly, Ruth O'Donnell, Huw D Lewis, Semantha Ellis, Neil Wilkie, Thomas W Rosahl, Philippe A Laroque, Christine Boussiquet-Leroux, Ian Churcher, John R Atack, Timothy Harrison, Mark S Shearman
