日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension

内皮细胞ADAR1缺陷诱导肺动脉高压中的NOCT-IRF7轴激活

Woodcock, Chen-Shan Chen; Maroli, Giovanni; Kim, Hyunbum; Tai, Yi Yin; Tang, Ying; Okawa, Satoshi; Homsi, Rami; Kim, Yunhye; Cho, Shu-Ting; Jiang, Siyi; Chauvet, Caroline; Wang, Bing; Al Aaraj, Yassmin; Lafyatis, Robert; Saggar, Rajan; Sembrat, John; Wang, Qingde; Li, Qin; Frump, Andrea L; Lahm, Tim; McCubbrey, Alexandra L; Kudryashova, Tatiana V; Goncharova, Elena A; Nouraie, Seyed Mehdi; Bertero, Thomas; Yuan, Ke; Pullamsetti, Soni S; Chan, Stephen Y

Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation.

组织驻留巨噬细胞的存活依赖于线粒体功能,而线粒体功能在慢性炎症中受 SerpinB2 调控。

Vasamsetti Sathish Babu, Sadaf Samreen, Uddin Mohammad A, Shen Jixing, Johny Ebin, Mondal Awishi, Florentin Jonathan, Lei Liqun, Mannan Aleef, Rao Krithika Sudhakar, Sembrat John, Rojas Mauricio, Sipula Ian, Kastroll Jake, Jurczak Michael J, Shiva Sruti, O'Doherty Robert M, Yechoor Vijay, Dutta Partha

A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases

用于解析细胞动力学和复杂疾病计算机辅助药物发现的深度生成模型

Zheng, Yumin; Schupp, Jonas C; Adams, Taylor; Clair, Geremy; Justet, Aurelien; Ahangari, Farida; Yan, Xiting; Hansen, Paul; Carlon, Marianne; Cortesi, Emanuela; Vermant, Marie; Vos, Robin; De Sadeleer, Laurens J; Rosas, Ivan O; Pineda, Ricardo; Sembrat, John; Königshoff, Melanie; McDonough, John E; Vanaudenaerde, Bart M; Wuyts, Wim A; Kaminski, Naftali; Ding, Jun

Altered AP-1, RUNX, and EGR chromatin dynamics drive human fibrotic lung disease

AP-1、RUNX 和 EGR 染色质动力学的改变驱动人类纤维化肺病

Valenzi, Eleanor; Jia, Minxue; Gerges, Peter; Fan, Jingyu; Tabib, Tracy; Behera, Rithika; Mao, Haiyi; Xue, Dan; Ju, Eun Mi; Zhou, Yuechen; Sembrat, John C; Das, Jishnu; Benos, Panayiotis V; Singh, Harinder; Lafyatis, Robert

Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease.

非经典TERT活性启动钙化性主动脉瓣疾病中的骨生成

Cuevas Rolando A, Hortells Luis, Chu Claire C, Wong Ryan, Crane Alex, Boufford Camille K, Regan Cailyn, Moorhead William J 3rd, Bashline Michael J, Parwal Aneesha, Parise Angelina M, Behzadi Parya, Brown Mark J, Gurkar Aditi U, Bruemmer Dennis, Sembrat John, Sultan Ibrahim, Gleason Thomas G, Billaud Marie, St Hilaire Cynthia

Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models.

抑制上皮细胞 YAP-TEAD/LOX 信号传导可减轻临床前模型中的肺纤维化

Wagner Darcy Elizabeth, Alsafadi Hani N, Mitash Nilay, Justet Aurelien, Hu Qianjiang, Pineda Ricardo, Staab-Weijnitz Claudia, Korfei Martina, Gvazava Nika, Wannemo Kristin, Onwuka Ugochi, Mozurak Molly, Estrada-Bernal Adriana, Cala-Garcia Juan, Mutze Katrin, Costa Rita, Bölükbas Deniz, Stegmayr John, Skronska-Wasek Wioletta, Klee Stephan, Ota Chiharu, Baarsma Hoeke A, Wang Jingtao, Sembrat John, Hilgendorff Anne, Ding Jun, Günther Andreas, Chambers Rachel, Rosas Ivan, de Langhe Stijn, Kaminski Naftali, Lehmann Mareike, Eickelberg Oliver, Königshoff Melanie

Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH.

通过 NOX1 调节肺内皮细胞 PERK、未折叠蛋白反应 (UPR) 和增殖的氧化还原反应:靶向抑制作为 PAH 的潜在疗法

Goossen Christian J, Kufner Alex, Dustin Christopher M, Al Ghouleh Imad, Yuan Shuai, Straub Adam C, Sembrat John, Baust Jeffrey J, Gomez Delphine, Kračun Damir, Pagano Patrick J

NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction

NKG2D阻断会损害组织驻留记忆T细胞的积累,并减少慢性肺移植功能障碍。

Moghbeli, Kaveh; Lipp, Madeline A; Bueno, Marta; Craig, Andrew; Rojas, Michelle; Abbas, Minahal; Lakkis, Zachary I; Chuan, Byron; Sembrat, John; Noda, Kentaro; Kass, Daniel J; Chen, Kong; Fan, Li; Oury, Tim; Zhou, Zihe; Wang, Xingan; McDyer, John F; Eickelberg, Oliver; Snyder, Mark E

Targeting cannabinoid receptor 1 for antagonism in pro-fibrotic alveolar macrophages mitigates pulmonary fibrosis

靶向拮抗促纤维化肺泡巨噬细胞中的大麻素受体1可减轻肺纤维化

Basu, Abhishek; Arif, Muhammad; Wolf, Kaelin M; Behee, Madeline; Johnson, Natalie; Pommerolle, Lenny; Pineda, Ricardo H; Sembrat, John; Zawatsky, Charles N; Dvorácskó, Szabolcs; Coffey, Nathan J; Park, Joshua K; Karagoz, Seray B; Godlewski, Grzegorz; Jourdan, Tony; Harvey-White, Judith; Königshoff, Melanie; Iyer, Malliga R; Cinar, Resat

VX-445 (elexacaftor) inhibits chloride secretion across human bronchial epithelial cells by directly blocking KCa3.1 channels

VX-445(依来卡托)通过直接阻断KCa3.1通道抑制人支气管上皮细胞的氯离子分泌。

Kolski-Andreaco, Aaron; Balut, Corina M; Green, Matthew D; Sembrat, John; Bridges, Robert J; Singh, Ashvani K; Tse, Chris; Butterworth, Michael B; Devor, Daniel C