日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease

靶向线粒体网络紊乱对秀丽隐杆线虫亨廷顿病模型具有保护作用

Machiela, Emily; Rudich, Paige D; Traa, Annika; Anglas, Ulrich; Soo, Sonja K; Senchuk, Megan M; Van Raamsdonk, Jeremy M

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease

在帕金森病G2019S LRRK2线虫模型中,多个调控寿命延长的基因通路具有神经保护作用。

Senchuk, Megan M; Van Raamsdonk, Jeremy M; Moore, Darren J

α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease

单拷贝转基因的 α-突触核蛋白表达增加了对压力的敏感性并加速了帕金森病遗传模型中的神经元丢失

Jason F Cooper, Katie K Spielbauer, Megan M Senchuk, Saravanapriah Nadarajan, Monica P Colaiácovo, Jeremy M Van Raamsdonk

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

线粒体未折叠蛋白反应转录因子ATFS-1通过激活应激反应通路促进长寿线粒体突变体的寿命

Wu, Ziyun; Senchuk, Megan M; Dues, Dylan J; Johnson, Benjamin K; Cooper, Jason F; Lew, Leira; Machiela, Emily; Schaar, Claire E; DeJonge, Heather; Blackwell, T Keith; Van Raamsdonk, Jeremy M

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

活性氧激活DAF-16/FOXO有助于秀丽隐杆线虫长寿线粒体突变体的寿命延长。

Senchuk, Megan M; Dues, Dylan J; Schaar, Claire E; Johnson, Benjamin K; Madaj, Zachary B; Bowman, Megan J; Winn, Mary E; Van Raamsdonk, Jeremy M

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.

秀丽隐杆线虫长寿 isp-1 线粒体突变体中氧化应激抵抗力与寿命的脱钩

Dues Dylan J, Schaar Claire E, Johnson Benjamin K, Bowman Megan J, Winn Mary E, Senchuk Megan M, Van Raamsdonk Jeremy M

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

新型动物模型确定了 α-突触核蛋白在神经元间转移的遗传贡献

Trevor Tyson, Megan Senchuk, Jason F Cooper, Sonia George, Jeremy M Van Raamsdonk, Patrik Brundin

Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays

测量秀丽隐杆线虫的氧化应激:百草枯和胡桃醌敏感性试验

Megan M Senchuk, Dylan J Dues, Jeremy M Van Raamsdonk

Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models

延缓衰老对帕金森病具有神经保护作用:秀丽隐杆线虫模型遗传分析

Cooper, Jason F; Dues, Dylan J; Spielbauer, Katie K; Machiela, Emily; Senchuk, Megan M; Van Raamsdonk, Jeremy M

Self-monitoring of blood glucose in Black Caribbean and South Asian Canadians with non-insulin treated Type 2 diabetes mellitus: a qualitative study of patients' perspectives

针对未接受胰岛素治疗的2型糖尿病黑人加勒比裔和南亚裔加拿大人的血糖自我监测:一项关于患者视角的定性研究

Gucciardi, Enza; Fortugno, Mariella; Senchuk, Andrea; Beanlands, Heather; McCay, Elizabeth; Peel, Elizabeth E