Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors
优化3-嘧啶-4-基-噁唑烷-2-酮类化合物作为口服生物利用度高且能穿透血脑屏障的突变型IDH1抑制剂
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.8b00182
Zhao, Qian; Manning, James R; Sutton, James; Costales, Abran; Sendzik, Martin; Shafer, Cynthia M; Levell, Julian R; Liu, Gang; Caferro, Thomas; Cho, Young Shin; Palermo, Mark; Chenail, Gregg; Dooley, Julia; Villalba, Brian; Farsidjani, Ali; Chen, Jinyun; Dodd, Stephanie; Gould, Ty; Liang, Guiqing; Slocum, Kelly; Pu, Minying; Firestone, Brant; Growney, Joseph; Heimbach, Tycho; Pagliarini, Raymond