日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage

染色质调节因子HELLS介导单链断裂修复和对DNA烷基化损伤的反应。

Joyous T Joseph,Christine M Wright,Estanislao Peixoto,Etsuko Shibata,Asad Khan,Yong Li,Jason S Romero Neidigk,Bo-Ruei Chen,Saba Tufail,Aaiyas Abdulhamid Mujawar,Olivia Decker,Krishna Reethika Kadali,Azait Imtiaz,Brianna A Jones,Yanfeng Zhang,Sergio A Gradilone,Zachary A Lewis    ,Rafael Contreras-Galindo,Arko Sen,Anindya Dutta,Wioletta Czaja

NAMPT Overexpression Drives Cell Growth in Polycystic Liver Disease through Mitochondrial Metabolism Regulation

NAMPT 过表达通过线粒体代谢调节推动多囊肝细胞生长

Kishor Pant, Sergio A Gradilone

The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth

NAMPT 抑制剂 FK866 与顺铂联合使用可抑制胆管癌细胞生长

Kishor Pant, Seth Richard, Estanislao Peixoto, Jun Yin, Davis M Seelig, Pietro Carotenuto, Massimiliano Salati, Brunella Franco, Lewis R Roberts, Sergio A Gradilone

Inhibition of triple‑negative breast cancer proliferation and motility by reactivating p53 and inhibiting overactivated Akt

通过重新激活 p53 和抑制过度激活的 Akt 来抑制三阴性乳腺癌的增殖和迁移

Wei Cao #, Renhui Shen #, Seth Richard, Yu Liu, Mohammad Jalalirad, Margot P Cleary, Antonio B D'Assoro, Sergio A Gradilone, Da-Qing Yang

HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models

HDAC6 依赖性纤毛吞噬作用与人类细胞和小鼠模型中的纤毛丢失和胆管癌生长有关

Estanislao Peixoto, Sujeong Jin, Kristen Thelen, Aalekhya Biswas, Seth Richard, Manuela Morleo, Adrian Mansini, Stephanie Holtorf, Fabrizia Carbone, Nunzia Pastore, Andrea Ballabio, Brunella Franco, Sergio A Gradilone

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

组蛋白去乙酰化酶 6 抑制剂与生长抑素受体激动剂的组合可协同减少多囊肝病动物模型中的肝肾囊肿形成

Maria Lorenzo Pisarello, Tatyana V Masyuk, Sergio A Gradilone, Anatoliy I Masyuk, Jingyi F Ding, Pui-Yuen Lee, Nicholas F LaRusso

Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma

非典型 Hedgehog 信号促进胆管癌趋化

Nataliya Razumilava, Sergio A Gradilone, Rory L Smoot, Joachim C Mertens, Steven F Bronk, Alphonse E Sirica, Gregory J Gores

Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression

中心体异常是人类和啮齿动物囊性胆管细胞的特征,与 Cdc25A 过度表达有关

Tatyana V Masyuk, Seung-Ok Lee, Brynn N Radtke, Angela J Stroope, Bing Huang, Jesús M Banales, Anatoliy I Masyuk, Patrick L Splinter, Sergio A Gradilone, Gabriella B Gajdos, Nicholas F LaRusso

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

TGR5 的纤毛亚细胞定位决定了胆管细胞对胆汁酸信号的功能反应

Anatoliy I Masyuk, Bing Q Huang, Brynn N Radtke, Gabriella B Gajdos, Patrick L Splinter, Tatyana V Masyuk, Sergio A Gradilone, Nicholas F LaRusso

Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD

Trpv4 的激活可降低 ARPKD 动物模型中囊性胆管细胞的过度增殖表型

Sergio A Gradilone, Tatyana V Masyuk, Bing Q Huang, Jesus M Banales, Guillermo L Lehmann, Brynn N Radtke, Angela Stroope, Anatoliy I Masyuk, Patrick L Splinter, Nicholas F LaRusso