日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer's disease

一个与早发性阿尔茨海默病相关的PSEN1杂合功能缺失变异体的奇特案例

期刊:
影响因子:
doi:10.1186/s44477-025-00004-x
Sanjuan-Ruiz, Inmaculada; Serneels, Lutgarde; Craessaerts, Katleen; Goate, Alison; Annaert, Wim; Chávez-Gutiérrez, Lucía; Shi, Yonggang; Sheikh-Bahaei, Nasim; Jen, Joanna C; Ramos, Eliana Marisa; Campan, Mihaela; Ward, Pamela M; Magaki, Shino; Bartlone, Kelly; Vinters, Harry V; Craig, David W; Ringman, John M; De Strooper, Bart
阿尔茨海默症
发表日期：2025
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The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer's Disease.

与早发性阿尔茨海默病相关的杂合功能丧失型PSEN1变异体的奇特案例

期刊:
影响因子:
doi:10.21203/rs.3.rs-7222993/v1
Ruiz Inmaculada Sanjuan, Serneels Lutgarde, Craessaerts Katleen, Goate Alison, Annaert Wim, Gutierrez Lucia Chavez, Shi Yonggang, Sheikh-Bahaei Nasim, Jen Joanna C, Ramos Eliana Marisa, Campan Mihaela, Ward Pamela M, Magaki Shino, Bartlone Kelly, Vinters Harry V, Craig David W, Ringman John M, Strooper Bart
其它
发表日期：2025
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Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex

PSENEN（γ-分泌酶复合物的第四个亚基）的功能和拓扑分析

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2023.105533
Serneels, Lutgarde; Bammens, Leen; Zwijsen, An; Tolia, Alexandra; Chávez-Gutiérrez, Lucía; De Strooper, Bart
发表日期：2024
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MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease

MEG3激活模拟阿尔茨海默病的人类神经元异种移植模型中的坏死性凋亡

期刊:Science
影响因子:45.8
doi:10.1126/science.abp9556
Balusu, Sriram; Horré, Katrien; Thrupp, Nicola; Craessaerts, Katleen; Snellinx, An; Serneels, Lutgarde; T'Syen, Dries; Chrysidou, Iordana; Arranz, Amaia M; Sierksma, Annerieke; Simrén, Joel; Karikari, Thomas K; Zetterberg, Henrik; Chen, Wei-Ting; Thal, Dietmar Rudolf; Salta, Evgenia; Fiers, Mark; De Strooper, Bart
阿尔茨海默症
凋亡
表观遗传
神经科学
发表日期：2023
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Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease

在小鼠和大鼠中构建β-分泌酶切割位点模型并人源化β-淀粉样前体蛋白，以研究阿尔茨海默病

期刊:Molecular Neurodegeneration
影响因子:17.5
doi:10.1186/s13024-020-00399-z
Serneels, Lutgarde; T'Syen, Dries; Perez-Benito, Laura; Theys, Tom; Holt, Matthew G; De Strooper, Bart
阿尔茨海默症
Rat
发表日期：2020
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Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

Nestin-Cre小鼠的代谢和行为表型是由下丘脑表达人类生长激素引起的

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0135502
Declercq, Jeroen; Brouwers, Bas; Pruniau, Vincent P E G; Stijnen, Pieter; de Faudeur, Geoffroy; Tuand, Krizia; Meulemans, Sandra; Serneels, Lutgarde; Schraenen, Anica; Schuit, Frans; Creemers, John W M
神经科学
代谢
Human
Nestin
免疫/内分泌
发表日期：2015
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β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.

β-分泌酶（BACE1）抑制通过血管功能紊乱和老年色素的积累引起视网膜病变

期刊:EMBO Molecular Medicine
影响因子:8.3
doi:10.1002/emmm.201101084
Cai Jun, Qi Xiaoping, Kociok Norbert, Skosyrski Sergej, Emilio Alonso, Ruan Qing, Han Song, Liu Li, Chen Zhijuan, Bowes Rickman Catherine, Golde Todd, Grant Maria B, Saftig Paul, Serneels Lutgarde, de Strooper Bart, Joussen Antonia M, Boulton Michael E
心血管
发表日期：2012
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Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy

阿尔茨海默病：保留早老素2的γ-分泌酶抑制剂是一种耐受性良好的降低Aβ肽水平的策略

期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.1451-12.2012
Borgegård, Tomas; Gustavsson, Susanne; Nilsson, Charlotte; Parpal, Santiago; Klintenberg, Rebecka; Berg, Anna-Lena; Rosqvist, Susanne; Serneels, Lutgarde; Svensson, Samuel; Olsson, Fredrik; Jin, Shaobo; Yan, Hongmei; Wanngren, Johanna; Jureus, Anders; Ridderstad-Wollberg, Anna; Wollberg, Patrik; Stockling, Kenneth; Karlström, Helena; Malmberg, Asa; Lund, Johan; Arvidsson, Per I; De Strooper, Bart; Lendahl, Urban; Lundkvist, Johan
阿尔茨海默症
发表日期：2012
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Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway

Rer1p与APH-1竞争结合尼卡斯特林，并在早期分泌途径中调控γ-分泌酶复合物的组装。

期刊:Journal of Cell Biology
影响因子:6.4
doi:10.1083/jcb.200609180
Spasic, Dragana; Raemaekers, Tim; Dillen, Katleen; Declerck, Ilse; Baert, Veerle; Serneels, Lutgarde; Füllekrug, Joachim; Annaert, Wim
信号转导
发表日期：2007
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Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

过氧化物酶体增殖激活受体γ诱导淀粉样β肽的清除机制

期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.3987-04.2004
Camacho Ira Espuny, Serneels Lutgarde, Spittaels Kurt, Merchiers Pascal, Dominguez Diana, De Strooper Bart
其它
发表日期：2004
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