日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.

诱导性删除小胶质细胞中的 DGAT1 和 2 会加剧雄性 PS19 小鼠的神经退行性变和内溶酶体脂质积累。

Tabor G Travis, Litvinchuk Alexandra, Chen Yun, Allison Austin, Sun Elizabeth W, van Lengerich Bettina, Davis Sonnet S, West Elizabeth, Schlachetzki Johannes C M, Zeng Carisa, Hu Hao, Lin Peter B, Sharma Prabal, Chen Xiaoying, Parhizkar Samira, Song Sihui, Bao Xin, Senthil Lakshita, Iyer Abhirami K, You Shih Feng, Serrano Javier Remolina, Manis Melissa, Franke Emily, Cashikar Anil G, Yuede Carla M, Suh Jung H, Karch Celeste M, Folick Andrew, Koliwad Suneil K, Farese Robert V Jr, Walther Tobias, Huang Eric J, Artyomov Maxim, Glass Christopher K, Di Paolo Gilbert, Ulrich Jason D, Holtzman David M

Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy.

在 tau 蛋白病小鼠模型中,Lemborexant 可改善 tau 蛋白介导的雄性睡眠丧失和神经退行性变

Parhizkar Samira, Bao Xin, Chen Wei, Rensing Nicholas, Chen Yun, Kipnis Michal, Song Sihui, Gent Grace, Tycksen Eric, Manis Melissa, Lee Choonghee, Serrano Javier Remolina, Bosch Megan E, Franke Emily, Yuede Carla M, Landsness Eric C, Wong Michael, Holtzman David M

Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

更正:在tau蛋白病小鼠模型中,AAV介导的抗tau scFv表达可减少tau蛋白的积累。

Ising, Christina; Gallardo, Gilbert; Leyns, Cheryl E G; Wong, Connie H; Jiang, Hong; Stewart, Floy; Koscal, Lauren J; Roh, Joseph; Robinson, Grace O; Serrano, Javier Remolina; Holtzman, David M