日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BRAF(V600E) patient derived colon cancer organoids identify biomarkers of response to EGFR and BRAF inhibition and replicate clinical data

BRAF(V600E)患者来源的结肠癌类器官可识别EGFR和BRAF抑制剂疗效的生物标志物,并能重现临床数据。

Kotarac, Anna; Osumi, Hiroki; Malt, Alexander; Alp, Keziban Merve; Jarosch, Armin; Werner, Johannes; Benary, Manuela; Neumann, Christopher C M; Yao, Ryoji; Mertins, Philipp; Eils, Roland; Beule, Dieter; Sers, Christine; Keilholz, Ulrich; Ishaque, Naveed; Stintzing, Sebastian; Vecchione, Loredana

Cancer evolution and multi-omic profile of relapsed colorectal liver metastases after treatment

治疗后复发性结直肠肝转移的癌症演变和多组学特征

Tomás, Laura; Raschzok, Nathanael; Blanc, Eric; Gallardo-Gómez, María; Menne, Andrea; Astrahantseff, Kathy; De Chiara, Loretta; Geisel, Dominik; Pratschke, Johann; Modest, Dominik P; Eggert, Angelika; Beule, Dieter; Posada, David; Sers, Christine; Mamlouk, Soulafa

Tumor mutations predict HER2-targeted therapy resistance in primary HER2-positive breast cancer

肿瘤突变可预测原发性HER2阳性乳腺癌对HER2靶向治疗的耐药性

Van Mackelenbergh, Marion T; Pfarr, Nicole; Weber, Karsten; Untch, Michael; Solbach, Christine; Schneeweiss, Andreas; Jank, Paul; Blohmer, Jens; Treue, Denise; Schmatloch, Sabine; Lehmann, Annika; Hanusch, Claus; Link, Theresa; Sers, Christine; Bjelic-Radisic, Vesna; Hummel, Michael; Huober, Jens; Schmitt, Wolfgang D; Fasching, Peter A; Aktas, Bahriye; Rhiem, Kerstin; Reinisch, Mattea; Nekljudova, Valentina; Denkert, Carsten; Loibl, Sibylle

Proteomic profiling of colorectal liver metastases reveals histopathological response-specific molecular signatures of chemotherapy efficacy

结直肠癌肝转移的蛋白质组学分析揭示了化疗疗效的组织病理学反应特异性分子特征。

Böhm, Agnes K; Skrip, Lisa M; Klein, Oliver; Strobl, Felix; Wieland, Jonas K; Arnold, Alexander; Zhou, Yijun; Papke, Björn; Sers, Christine; Modest, Dominik P; Moosburner, Simon; Haber, Philipp K; Krenzien, Felix; Raschzok, Nathanael; Schöning, Wenzel; Horst, David; Malinka, Thomas; Sack, Ingolf; Pratschke, Johann; Sauer, Igor M; Hillebrandt, Karl H

GPA33 expression in colorectal cancer can be induced by WNT inhibition and targeted by cellular therapy.

结直肠癌中 GPA33 的表达可通过 WNT 抑制诱导,并可通过细胞疗法进行靶向治疗

Börding Teresa, Janik Tobias, Bischoff Philip, Morkel Markus, Sers Christine, Horst David

Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue

对患者匹配的新鲜和福尔马林固定石蜡包埋 (FFPE) 肺癌组织的单细胞 RNA 谱中具有临床相关特征的稳健检测

Trinks, Alexandra; Milek, Miha; Beule, Dieter; Kluge, Julie; Florian, Stefan; Sers, Christine; Horst, David; Morkel, Markus; Bischoff, Philip

BannMI deciphers potential n-to-1 information transduction in signaling pathways to unravel message of intrinsic apoptosis

BannMI 破译信号通路中潜在的 n 对 1 信息转导,以揭示内在凋亡的信息

Schmidt, Bettina; Sers, Christine; Klein, Nadja

DNA methylation-based classifier differentiates intrahepatic pancreato-biliary tumours

基于DNA甲基化的分类器可区分肝内胰胆肿瘤

Dragomir, Mihnea P; Calina, Teodor G; Perez, Eilís; Schallenberg, Simon; Chen, Meng; Albrecht, Thomas; Koch, Ines; Wolkenstein, Peggy; Goeppert, Benjamin; Roessler, Stephanie; Calin, George A; Sers, Christine; Horst, David; Roßner, Florian; Capper, David

Transcriptomic Deconvolution of Neuroendocrine Neoplasms Predicts Clinically Relevant Characteristics

神经内分泌肿瘤转录组解卷积预测临床相关特征

Otto, Raik; Detjen, Katharina M; Riemer, Pamela; Fattohi, Melanie; Grötzinger, Carsten; Rindi, Guido; Wiedenmann, Bertram; Sers, Christine; Leser, Ulf

Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression

在早期结直肠癌进展中,恶性转化和基因改变是分离的。

Mamlouk, Soulafa; Simon, Tincy; Tomás, Laura; Wedge, David C; Arnold, Alexander; Menne, Andrea; Horst, David; Capper, David; Morkel, Markus; Posada, David; Sers, Christine; Bläker, Hendrik