日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice

动力蛋白-2缺乏会导致小鼠出现与年龄和性别相关的粒细胞减少症和骨髓增生异常综合征。

Alexander J Willis ,Seth J Corey ,Carlos Murga-Zamalloa ,Saman S Karimi ,Karam Khaddour ,John Quigley ,Elizabeth A Eklund ,Yolande Chen

SBDSR126T rescues survival of sbds -/- zebrafish in a dose-dependent manner independently of Tp53

SBDSR126T 以剂量依赖性方式拯救 sbds -/- 斑马鱼的生存,且不依赖于 Tp53

Usua Oyarbide, Arish N Shah, Morgan Staton, Matthew Snyderman, Adya Sapra, Eliezer Calo, Seth J Corey

Loss of Sbds in zebrafish leads to neutropenia and pancreas and liver atrophy

斑马鱼中 Sbds 的缺失会导致中性粒细胞减少以及胰腺和肝脏萎缩

Usua Oyarbide, Arish N Shah, Wilmer Amaya-Mejia, Matthew Snyderman, Margaret J Kell, Daniela S Allende, Eliezer Calo, Jacek Topczewski, Seth J Corey

Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response

与疾病相关的 ELANE 突变的诱导表达会损害粒细胞分化,而不会引发未折叠蛋白反应

Bhavuk Garg, Hrishikesh M Mehta, Borwyn Wang, Ralph Kamel, Marshall S Horwitz, Seth J Corey

Effect of the unfolded protein response and oxidative stress on mutagenesis in CSF3R: a model for evolution of severe congenital neutropenia to myelodysplastic syndrome/acute myeloid leukemia

未折叠蛋白反应和氧化应激对 CSF3R 诱变的影响:严重先天性中性粒细胞减少症向骨髓增生异常综合征/急性髓系白血病演变的模型

Adya Sapra, Roman Jaksik, Hrishikesh Mehta, Sara Biesiadny, Marek Kimmel, Seth J Corey

mTOR and STAT3 Pathway Hyper-Activation is Associated with Elevated Interleukin-6 Levels in Patients with Shwachman-Diamond Syndrome: Further Evidence of Lymphoid Lineage Impairment

mTOR 和 STAT3 通路过度激活与 Shwachman-Diamond 综合征患者白细胞介素 6 水平升高有关:淋巴系受损的进一步证据

Antonio Vella, Elisabetta D'Aversa, Martina Api, Giulia Breveglieri, Marisole Allegri, Alice Giacomazzi, Elena Marinelli Busilacchi, Benedetta Fabrizzi, Tiziana Cestari, Claudio Sorio, Gloria Bedini, Giovanna D'Amico, Vincenzo Bronte, Antonella Poloni, Antonio Benedetti, Chiara Bovo, Seth J Corey, M

Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity

动力蛋白 2 和 3 通过调节 CXCR4 表面表达和 ITGB1 活性来控制人类巨核细胞的迁移

Praveen K Suraneni, Seth J Corey, Michael J Hession, Rameez Ishaq, Arinola Awomolo, Shirin Hasan, Chirag Shah, Hui Liu, Amittha Wickrema, Najet Debili, John D Crispino, Elizabeth A Eklund, Yolande Chen

Captopril mitigates splenomegaly and myelofibrosis in the Gata1low murine model of myelofibrosis

卡托普利可减轻Gata1low小鼠骨髓纤维化模型中的脾肿大和骨髓纤维化。

Seth J Corey ,Jyoti Jha ,Elizabeth A McCart ,William B Rittase ,Jeffy George ,Joseph J Mattapallil ,Hrishikesh Mehta ,Mungunsukh Ognoon ,Michelle A Bylicky ,Thomas A Summers ,Regina M Day

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

G-CSF 受体激活 Src 激酶 Lyn 是由 Gab2 募集 Shp2 磷酸酶介导的

Muneyoshi Futami, Quan-Sheng Zhu, Zakary L Whichard, Ling Xia, Yuehai Ke, Benjamin G Neel, Gen-Sheng Feng, Seth J Corey

Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias

达沙替尼抑制分子异质性髓系白血病的生长

Bella S Guerrouahen, Muneyoshi Futami, Christos Vaklavas, Jukka Kanerva, Zakary L Whichard, Kenechi Nwawka, Elisabeth G Blanchard, Francis Y Lee, Lisa J Robinson, Robert Arceci, Steven M Kornblau, Eric Wieder, Yvon E Cayre, Seth J Corey