日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle

癌细胞周期的异质性决定了药物 CDK2 抑制的敏感性

Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M Rubin, Costakis Frangou, Karen McLean, Agnieszka K Witkiewicz, Erik S Knudsen

Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics

针对细胞周期依赖性激酶-细胞周期蛋白结合的生物层干涉测定法揭示了 Cdk2 抑制剂对细胞周期蛋白结合动力学的不同影响

Carrie S Tambo, Sarvind Tripathi, B Gayani K Perera, Dustin J Maly, Alexander J Bridges, Gert Kiss, Seth M Rubin

The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes

MuvB 复合物结合并稳定细胞周期依赖性基因转录起始位点下游的核小体

Anushweta Asthana, Parameshwaran Ramanan, Alexander Hirschi, Keelan Z Guiley, Tilini U Wijeratne, Robert Shelansky, Michael J Doody, Haritha Narasimhan, Hinrich Boeger, Sarvind Tripathi, Gerd A Müller, Seth M Rubin

CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

CDK/细胞周期蛋白依赖性决定了癌细胞周期的极端异质性和附带脆弱性

Erik S Knudsen, Vishnu Kumarasamy, Ram Nambiar, Joel D Pearson, Paris Vail, Hanna Rosenheck, Jianxin Wang, Kevin Eng, Rod Bremner, Daniel Schramek, Seth M Rubin, Alana L Welm, Agnieszka K Witkiewicz

Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family

LxCxE 依赖性蛋白质与视网膜母细胞瘤蛋白家族相互作用的可调亲和力和特异性的结构基础

Sivasankar Putta, Lucia Alvarez, Stephan Lüdtke, Peter Sehr, Gerd A Müller, Samantha M Fernandez, Sarvind Tripathi, Joe Lewis, Toby J Gibson, Lucia B Chemes, Seth M Rubin

Cyclin-dependent kinase-mediated phosphorylation and the negative regulatory domain of transcription factor B-Myb modulate its DNA binding

细胞周期蛋白依赖性激酶介导的磷酸化和转录因子B-Myb的负调控域调节其DNA结合

Tilini U Wijeratne, Keelan Z Guiley, Hsiau-Wei Lee, Gerd A Müller, Seth M Rubin

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

细胞周期蛋白F通过SCF依赖性降解视网膜母细胞瘤样肿瘤抑制因子p130/RBL2来驱动细胞增殖。

Taylor P Enrico ,Wayne Stallaert ,Elizaveta T Wick ,Peter Ngoi ,Xianxi Wang ,Seth M Rubin ,Nicholas G Brown ,Jeremy E Purvis ,Michael J Emanuele

E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6

E2F4在多纤毛发生过程中的胞质作用是通过其N端结构域介导的,该结构域可结合中心粒复制机制的两个组分Deup1和SAS6。

Renin Hazan ,Munemasa Mori ,Paul S Danielian ,Vincent J Guen ,Seth M Rubin ,Wellington V Cardoso ,Jacqueline A Lees

A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae

酪氨酸磷酸调节系统控制霍乱弧菌胞外多糖的生物合成和生物膜的形成

Carmen Schwechheimer, Kassidy Hebert, Sarvind Tripathi, Praveen K Singh, Kyle A Floyd, Elise R Brown, Monique E Porcella, Jacqueline Osorio, Joseph T M Kiblen, Fernando A Pagliai, Knut Drescher, Seth M Rubin, Fitnat H Yildiz

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

p27 变构激活细胞周期蛋白依赖性激酶 4 并拮抗 palbociclib 抑制

Keelan Z Guiley, Jack W Stevenson, Kevin Lou, Krister J Barkovich, Vishnu Kumarasamy, Tilini U Wijeratne, Katharine L Bunch, Sarvind Tripathi, Erik S Knudsen, Agnieszka K Witkiewicz, Kevan M Shokat, Seth M Rubin