日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I

抑制极光激酶可诱导内源性逆转录元件通过RIG-I诱导I/III型干扰素反应。

Choy, Lisa; Norris, Stephen; Wu, Xiumin; Kolumam, Ganesh; Firestone, Ari; Settleman, Jeffrey; Stokoe, David

A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells

单步高剂量选择方案揭示癌细胞获得性抗癌激酶抑制的独特机制

Kenneth J Finn, Scott E Martin, Jeff Settleman

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors

靶向微管使耐药肺癌细胞对溶酶体途径抑制剂敏感

Tan-Min Chin, Gandhi T K Boopathy, Ellen P S Man, John G Clohessy, Eva Csizmadia, Margaret P Quinlan, Thomas Putti, Seow-Ching Wan, Chen Xie, Azhar Ali, Fhu Chee Wai, Yan Shan Ong, Boon-Cher Goh, Jeff Settleman, Wanjin Hong, Elena Levantini, Daniel G Tenen

Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein

裸鼹鼠 p53 蛋白的无端稳定和核积累

Marian M Deuker, Kaitlyn N Lewis, Maria Ingaramo, Jacob Kimmel, Rochelle Buffenstein, Jeff Settleman

Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation

通过自分泌 FGFR 通路激活,BRAF 驱动的肿瘤对 BRAF/MEK 双重抑制产生适应性抗性

Victoria E Wang, Jenny Y Xue, Dennie T Frederick, Yi Cao, Eva Lin, Catherine Wilson, Anatoly Urisman, David P Carbone, Keith T Flaherty, Rene Bernards, Piro Lito, Jeff Settleman, Frank McCormick

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

SHOC2 缺失与 MEK 抑制在 RAS 驱动型癌症中的合成致死相互作用

Rita Sulahian ,Jason J Kwon ,Katherine H Walsh ,Emma Pailler ,Timothy L Bosse ,Maneesha Thaker ,Diego Almanza ,Joshua M Dempster ,Joshua Pan ,Federica Piccioni ,Nancy Dumont ,Alfredo Gonzalez ,Jonathan Rennhack ,Behnam Nabet ,John A Bachman ,Amy Goodale ,Yenarae Lee ,Mukta Bagul ,Rosy Liao ,Adrija Navarro ,Tina L Yuan ,Raymond W S Ng ,Srivatsan Raghavan ,Nathanael S Gray ,Aviad Tsherniak ,Francisca Vazquez ,David E Root ,Ari J Firestone ,Jeff Settleman ,William C Hahn ,Andrew J Aguirre

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity

EGFR突变型肺癌对酪氨酸激酶抑制剂治疗的获得性耐药促进PARP抑制剂的敏感性

Lynnette Marcar ,Kankana Bardhan ,Liliana Gheorghiu ,Patrick Dinkelborg ,Heike Pfäffle ,Qi Liu ,Meng Wang ,Zofia Piotrowska ,Lecia V Sequist ,Kerstin Borgmann ,Jeffrey E Settleman ,Jeffrey A Engelman ,Aaron N Hata ,Henning Willers

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

系统识别癌细胞对自然杀伤细胞介导的免疫监视的脆弱性

Matthew F Pech, Linda E Fong, Jacqueline E Villalta, Leanne Jg Chan, Samir Kharbanda, Jonathon J O'Brien, Fiona E McAllister, Ari J Firestone, Calvin H Jan, Jeffrey Settleman

Challenges in validating candidate therapeutic targets in cancer

癌症候选治疗靶点验证面临的挑战

Settleman, Jeffrey; Sawyers, Charles L; Hunter, Tony

Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells

Ras-MEK 信号介导癌细胞中关键的 Chk1 依赖性 DNA 损伤反应

Ho-June Lee, Yi Cao, Victoria Pham, Elizabeth Blackwood, Catherine Wilson, Marie Evangelista, Christiaan Klijn, David Stokoe, Jeff Settleman