日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL

初始抗CD19 CAR T细胞疗法对复发/难治性大B细胞淋巴瘤患者后续抗CD22 CAR T细胞制备及临床疗效的影响

Yi-Jiun Su ,Anne Marijn Kramer ,Mark P Hamilton ,Neha Agarwal ,Hrishikesh K Srinagesh ,John H Baird ,Bita Sahaf ,Adam Kuo ,Zachary J Ehlinger ,Moksha H Desai ,Skyler P Rietberg ,Ramya Tunuguntla ,Shabnum Patel ,Harshini Chinnasamy ,Nikolaos Gkitsas-Long ,Dorota D Klysz ,Annie Kathleen Brown ,Sushma Bharadwaj ,Saurabh Dahiya ,Melody Smith ,Lori Muffly ,Crystal L Mackall ,Zinaida Good ,Steven A Feldman ,David B Miklos ,Matthew J Frank

Inosine induces stemness features in CAR-T cells and enhances potency

肌苷可诱导 CAR-T 细胞的干性特征并增强其效力

Dorota D Klysz,Carley Fowler,Meena Malipatlolla,Lucille Stuani,Katherine A Freitas,Yiyun Chen,Stefanie Meier,Bence Daniel,Katalin Sandor,Peng Xu,Jing Huang,Louai Labanieh,Vimal Keerthi,Amaury Leruste,Malek Bashti,Janette Mata-Alcazar,Nikolaos Gkitsas,Justin A Guerrero,Chris Fisher,Sunny Patel,Kyle Asano,Shabnum Patel,Kara L Davis,Ansuman T Satpathy,Steven A Feldman,Elena Sotillo,Crystal L Mackall

Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

同源性独立的靶向插入 (HITI) 可实现引导 CAR 敲入和高效的临床规模 CAR-T 细胞制造

Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G Mancini, Gavin L Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J Fisher, Annie K Brown, Ramya H Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L Mackall, Steven A Feldman

Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

输注后CAR TReg细胞可识别对CD19-CAR疗法耐药的患者

Zinaida Good # ,Jay Y Spiegel # ,Bita Sahaf ,Meena B Malipatlolla ,Zach J Ehlinger ,Sreevidya Kurra ,Moksha H Desai ,Warren D Reynolds ,Anita Wong Lin ,Panayiotis Vandris ,Fang Wu ,Snehit Prabhu ,Mark P Hamilton ,John S Tamaresis ,Paul J Hanson ,Shabnum Patel ,Steven A Feldman ,Matthew J Frank ,John H Baird ,Lori Muffly ,Gursharan K Claire ,Juliana Craig ,Katherine A Kong ,Dhananjay Wagh ,John Coller ,Sean C Bendall ,Robert J Tibshirani ,Sylvia K Plevritis ,David B Miklos ,Crystal L Mackall

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

GD2-CAR T 细胞疗法治疗 H3K27M 突变的弥漫性中线胶质瘤

Robbie G Majzner #, Sneha Ramakrishna #, Kristen W Yeom, Shabnum Patel, Harshini Chinnasamy, Liora M Schultz, Rebecca M Richards, Li Jiang, Valentin Barsan, Rebecca Mancusi, Anna C Geraghty, Zinaida Good, Aaron Y Mochizuki, Shawn M Gillespie, Angus Martin Shaw Toland, Jasia Mahdi, Agnes Reschke, Est

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

针对复发性或难治性 B 细胞恶性肿瘤成年患者的具有双重靶向 CD19 和 CD22 的 CAR-T 细胞治疗:一项 1 期临床试验

Jay Y Spiegel #, Shabnum Patel #, Lori Muffly #, Nasheed M Hossain, Jean Oak, John H Baird, Matthew J Frank, Parveen Shiraz, Bita Sahaf, Juliana Craig, Maria Iglesias, Sheren Younes, Yasodha Natkunam, Michael G Ozawa, Eric Yang, John Tamaresis, Harshini Chinnasamy, Zach Ehlinger, Warren Reynolds, Ra

A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies

参与者衍生的 HIV 异种移植模型可实现对自体免疫疗法的长期评估

Chase D McCann #, Christiaan H van Dorp #, Ali Danesh #, Adam R Ward, Thomas R Dilling, Talia M Mota, Elizabeth Zale, Eva M Stevenson, Shabnum Patel, Chanson J Brumme, Winnie Dong, Douglas S Jones, Thomas L Andresen, Bruce D Walker, Zabrina L Brumme, Catherine M Bollard, Alan S Perelson, Darrell J I

BCL-2 antagonism sensitizes cytotoxic T cell-resistant HIV reservoirs to elimination ex vivo

BCL-2 拮抗剂可增强细胞毒性 T 细胞抗性的 HIV 病毒库对体外消除的敏感性

Yanqin Ren, Szu Han Huang, Shabnum Patel, Winiffer D Conce Alberto, Dean Magat, Dughan Ahimovic, Amanda B Macedo, Ryan Durga, Dora Chan, Elizabeth Zale, Talia M Mota, Ronald Truong, Thomas Rohwetter, Chase D McCann, Colin M Kovacs, Erika Benko, Avery Wimpelberg, Christopher Cannon, W David Hardy, Al

HIV-Specific T Cells Can Be Generated against Non-escaped T Cell Epitopes with a GMP-Compliant Manufacturing Platform

可以使用符合 GMP 标准的制造平台针对非逃逸 T 细胞表位生成 HIV 特异性 T 细胞

Shabnum Patel, Ryo Hanajiri, Melanie Grant, Devin Saunders, Stacey Van Pelt, Michael Keller, Patrick J Hanley, Gary Simon, Douglas F Nixon, David Hardy, R Brad Jones, Catherine M Bollard

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells

潜伏 HIV 病毒库表现出对 CD8+ T 细胞清除的固有抵抗力

Szu-Han Huang, Yanqin Ren, Allison S Thomas, Dora Chan, Stefanie Mueller, Adam R Ward, Shabnum Patel, Catherine M Bollard, Conrad Russell Cruz, Sara Karandish, Ronald Truong, Amanda B Macedo, Alberto Bosque, Colin Kovacs, Erika Benko, Alicja Piechocka-Trocha, Hing Wong, Emily Jeng, Douglas F Nixon,