日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants

邻近标记蛋白质组学揭示了致病性SHP2变体的相互作用组重塑和定位改变

van Vlimmeren, Anne E; Tang, Lauren C; Jiang, Ziyuan; Iyer, Abhishek; Voleti, Rashmi; Krismer, Konstantin; Gaublomme, Jellert T; Jovanovic, Marko; Shah, Neel H

A Scalable Design for Proximity-Inducing Molecules

一种可扩展的邻近诱导分子设计

Karaj, Endri; Venkatarangan, Varsha; Sindi, Shaimaa H; Siriwongsup, Surached; Lee, Chaiheon; Pergu, Rajaiah; Sreekanth, Vedagopuram; Kailass, Karishma; Tran, Kien; Singh, Prashant; Singh, Sameek; Kawai, Junya; Fung, Jeffrey E; Tefera, Mahilet; Dhaliwal, Rohil; Chaudhary, Santosh K; Keyes, April; Sadagopan, Ananthan; Boatner, Lisa; Shah, Neel H; Fehl, Charlie; Backus, Keriann M; Choudhary, Amit

Deep mutational scanning of the multi-domain phosphatase SHP2 reveals mechanisms of regulation and pathogenicity.

对多结构域磷酸酶 SHP2 进行深度突变扫描,揭示了其调控和致病机制

Jiang Ziyuan, van Vlimmeren Anne E, Karandur Deepti, Semmelman Alyssa, Shah Neel H

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

酪氨酸磷酸酶 PTP1B 通过蛋白质-蛋白质相互作用进行变构调节

Chartier, Cassandra A; Woods, Virgil A; Xu, Yunyao; van Vlimmeren, Anne E; Johns, Andrew C; Jovanovic, Marko; McDermott, Ann E; Keedy, Daniel A; Shah, Neel H

Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression

利用肽结合实验和自由能回归法构建SH2结构域的精确亲和力模型

Gagoski, Dejan; Rube, H Tomas; Rastogi, Chaitanya; Melo, Lucas A N; Li, Xiaoting; Voleti, Rashmi; Shah, Neel H; Bussemaker, Harmen J

Profiling tyrosine kinase substrate recognition using bacterial peptide display and deep sequencing

利用细菌肽展示和深度测序技术分析酪氨酸激酶底物识别情况

Lee, Minhee; Shah, Neel H

Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression

利用多轮肽结合实验和自由能回归分析,构建SH2结构域的精确序列-亲和力模型

Gagoski, Dejan; Rube, H Tomas; Rastogi, Chaitanya; Melo, Lucas A N; Li, Xiaoting; Voleti, Rashmi; Shah, Neel H; Bussemaker, Harmen J

Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants

多重单细胞转录组学揭示致病性SHP2变异体的多种表型结果

van Vlimmeren, Anne E; Giglio, Ross M; Jiang, Ziyuan; Lee, Minhee; McFaline-Figueroa, José L; Shah, Neel H

Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2.

变构抑制可挽救由催化失活的 Shp2 引起的脑积水

Makrides Neoklis, Sun Emily, Mir Hilal, Jiang Ziyuan, Wu Yihua, Serra Carlos, Cardoso Wellington V, Shah Neel H, Zhang Xin

A Multiplexed SEC-MS Approach to Systematically Study the Interplay Between Protein Assembly-States and Phosphorylation Events

利用多重SEC-MS方法系统地研究蛋白质组装状态与磷酸化事件之间的相互作用

Doron-Mandel, Ella; Bokor, Benjamin Judah; Ma, Yanzhe; Street, Lena Annika; Tang, Lauren Clarissa; Abdou, Ahmed Ali; Shah, Neel H; Rosenberger, George; Jovanovic, Marko