日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hepatic adaptation to chronic metabolic stress primes tumorigenesis.

肝脏对慢性代谢应激的适应会促进肿瘤发生。

Tzouanas Constantine N, Shay Jessica E S, Sherman Marc S, Rubin Adam J, Mead Benjamin E, Dao Tyler T, Tao Junyan, Lehrich Brandon M, Eng George, Patterson-Fortin Jeffrey, Butzlaff Titus, Mana Miyeko D, Kolb Kellie E, Walesky Chad, Pepe-Mooney Brian J, Smith Colton J, Prakadan Sanjay M, Ramseier Michelle L, Tong Yuzhou Evelyn, Joung Julia, Chi Fangtao, McMahon-Skates Thomas, Winston Carolyn L, Jeong Woo-Jeong, Aney Katherine J, Chen Ethan, Nissim Sahar, Zhang Feng, Deshpande Vikram, Monga Satdarshan P, Lauer Georg M, Goessling Wolfram, Yilmaz Ömer H, Shalek Alex K

Same-Slide Spatial Multi-Omics Integration with IN-DEPTH Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment.

通过 IN-DEPTH 进行同一张载玻片空间多组学整合,揭示了肿瘤病毒相关的肿瘤微环境空间重组。

Yiu Stephanie Pei Tung, Chang Yuzhou, Yeo Yao Yu, Qiu Huaying, Wu Wenrui, Michel Hendrik A, Jin Xiaojie, Huang Rongting, Kure Shoko, Parmelee Lindsay, Luo Shuli, Cramer Precious, Lee Jia Le, Wang Yang, Zhao Zhangxin, Yeung Jason, El Ahmar Nourhan, Simsek Berkay, Mohanna Razan, Van Orden McKayla, Lu Wesley S, Livak Kenneth J, Li Shuqiang, Gao Ce, Burgess Melinda, Keane Colm, Shahryari Jahanbanoo, Kingsley Leandra G, Al-Humadi Reem N, Nasr Sahar, Nkosi Dingani, Sadigh Sam, Rock Philip, Frauenfeld Leonie, Kaufmann Louisa, Zhu Bokai, Basak Ankit, Dhanikonda Nagendra, Chan Chi Ngai, Krull Jordan, Cho Ye Won, Chen Chia-Yu, Brown Jonathan, Wang Hongbo, Zhao Bo, Lee Jia-Ying Joey, Loo Lit-Hsin, Kim David M, Boussiotis Vassiliki A, Zhang Baochun, Wei Kevin, Shalek Alex K, Howitt Brooke E, Signoretti Sabina, Schürch Christian M, Hodi F Stephen, Burack W Richard, Rodig Scott J, Ma Qin, Jiang Sizun

Multiomic, Histologic, and scRNA-seq Profiling of Pleural Mesothelioma Reveals Negative Prognosis Associated With a Novel Uncommitted Molecular Phenotype

胸膜间皮瘤的多组学、组织学和单细胞RNA测序分析揭示了一种与新型未分化分子表型相关的不良预后

Severson, David T; Freyaldenhoven, Samuel; Wadowski, Benjamin; Hung, Yin P; Hughes, Travis; Yeap, Beow Y; Richards, William G; Laaksonen, Sanna; Chirieac, Lucian; Couger, Matthew B; Jensen, Roderick V; Sadek, Ahmed A; Ilonen, Ilkka; Vermilya, Kimberly; Innocenti, Simona; Korle, Stephanie L; Barlow, Julianne S; Anderson, Jamie; Meyerovitz, Jason; Wang, Vivian; Dao, Mary N; Shalek, Alex K; De Rienzo, Assunta; Bueno, Raphael

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology.

单细胞和空间分析表明,结核病诱导的肌成纤维细胞是肺部病理的驱动因素。

Mbano Ian M, Liu Nuo, Wadsworth Marc H 2nd, Chambers Mark J, Mpotje Thabo, Asowata Osaretin E, Nyquist Sarah K, Nargan Kievershen, Ramsuran Duran, Karim Farina, Hughes Travis K, Bromley Joshua D, Krause Robert, Naidoo Threnesan, Tezera Liku B, Reichmann Michaela T, Ganchua Sharie Keanne, Kløverpris Henrik N, Dullabh Kaylesh J, Madansein Rajhmun, Triana Sergio, Steyn Adrie J C, Berger Bonnie, Marakalala Mohlopheni J, Pollara Gabriele, Fortune Sarah M, Flynn JoAnne L, Elkington Paul T, Shalek Alex K, Leslie Alasdair

Toward Computationally Complete Spatial Omics

迈向计算完整的空间组学

Li, Wei; Mao, Liran; Liu, Yunhe; Peng, Fuduan; Sachs, Nadja; Wu, Wenrui; Yiu, Stephanie Pei Tung; Yan, Hanying; Schroeder, Amelia; Yu, Xiaokang; Jin, Kaitian; Jiang, Shunzhou; Chen, Zihao; Loth, Melanie L; Gomez, Lorena; Lubo, Idania; Blank, Niklas; Samarah, Laith Z; Basak, Ankit; Cho, Ye Won; Chen, Chia-Yu; Kim, David M; Shalek, Alex K; Soto, Luisa Maren Solis; Rabinowitz, Joshua D; Reilly, Muredach P; Qian, Xuyu; Thaiss, Christoph A; Maegdefessel, Lars; Wang, Linghua; Kadara, Humam; Jiang, Sizun; Deng, Yanxiang; Li, Mingyao

A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment

肠道组织微环境中宿主-微生物组解析的多组学空间框架

Zhu, Bokai; Bai, Yunhao; Yeo, Yao Yu; Lu, Xiaowei; Rovira-Clavé, Xavier; Chen, Han; Yeung, Jason; Nkosi, Dingani; Glickman, Jonathan; Delgado-Gonzalez, Antonio; Gerber, Georg K; Angelo, Mike; Shalek, Alex K; Nolan, Garry P; Jiang, Sizun

Host-intrinsic and host-extrinsic factors modulate immunity to Mtb infection, reinfection, and noncanonical vaccination routes

宿主内在因素和宿主外在因素调节对结核分枝杆菌感染、再感染和非典型疫苗接种途径的免疫力

Bromley, Joshua D; Simonson, Andrew W; Shalek, Alex K; Flynn, JoAnne L

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.

自身免疫性疾病风险基因 ANKRD55 通过代谢调节促进 TH17 效应功能。

Xu Jinjin, Kong Lingjia, Creasey Elizabeth A, Rath Sneha, Deng Lei, Avila-Pacheco Julian, Li Chenhao, Oliver Blayne A, Dao Tyler T, Shih Angela R, Daly Mark J, Shalek Alex K, Clish Clary B, Graham Daniel B, Deguine Jacques, Xavier Ramnik J

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.

COVID-19 肝脏的单核和空间转录组图谱揭示了患者的拓扑、功能和再生器官破坏

Pita-Juarez Yered, Karagkouni Dimitra, Kalavros Nikolaos, Melms Johannes C, Niezen Sebastian, Delorey Toni M, Essene Adam L, Brook Olga R, Pant Deepti, Skelton-Badlani Disha, Naderi Pourya, Huang Pinzhu, Pan Liuliu, Hether Tyler, Andrews Tallulah S, Ziegler Carly G K, Reeves Jason, Myloserdnyy Andriy, Chen Rachel, Nam Andy, Phelan Stefan, Liang Yan, Gregory Mark, He Shanshan, Patrick Michael, Rane Tushar, Wardhani Aster, Amin Amit Dipak, Biermann Jana, Hibshoosh Hanina, Veregge Molly, Kramer Zachary, Jacobs Christopher, Yalcin Yusuf, Phillips Devan, Slyper Michal, Subramanian Ayshwarya, Ashenberg Orr, Bloom-Ackermann Zohar, Tran Victoria M, Gomez James, Sturm Alexander, Zhang Shuting, Fleming Stephen J, Warren Sarah, Beechem Joseph, Hung Deborah, Babadi Mehrtash, Padera Robert F Jr, MacParland Sonya A, Bader Gary D, Imad Nasser, Solomon Isaac H, Miller Eric, Riedel Stefan, Porter Caroline B M, Villani Alexandra-Chloé, Tsai Linus T-Y, Hide Winston, Szabo Gyongyi, Hecht Jonathan, Rozenblatt-Rosen Orit, Shalek Alex K, Izar Benjamin, Regev Aviv, Popov Yury V, Jiang Z Gordon, Vlachos Ioannis S

Artificial variables help to avoid over-clustering in single-cell RNA sequencing

人工变量有助于避免单细胞RNA测序中的过度聚类。

DenAdel, Alan; Ramseier, Michelle L; Navia, Andrew W; Shalek, Alex K; Raghavan, Srivatsan; Winter, Peter S; Amini, Ava P; Crawford, Lorin