日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Target-Centric Multiplexed Screening of an Herbal Extract Identifies a Novel Dual A(2A)/A(2B) Receptor Antagonist for Cancer Immunotherapy.

以目标为中心的多重筛选草药提取物,发现了一种用于癌症免疫疗法的新型双重 A(2A)/A(2B) 受体拮抗剂。

Liu Hongyue, Yang Xinyu, Xu Jingyi, Wang Yuefei, Zhao Zichen, Quan Ke, Gao Aoqi, Wang Yang, Wu Jingbo, Li Fei, Zhang Zhaoyu, Ma Yuanyuan, Weng Yuan, Chen Ying, Sun Liping, Song Gaojie, Shan Yibing, Chai Xin, Zhang Bingjie, Lu Weiqiang, Shui Wenqing

Experimental variables determine the outcome of RAS-RAS interactions.

实验变量决定了 RAS-RAS 相互作用的结果

Zhou Zhiwei, Nguyen Tra Ly, Li Xingxiao, Poujol Christel, Berlinska Ewa, Michelina Sandra Vietti, Kapp Jonas N, Plückthun Andreas, Winslow Monte M, Ambrogio Chiara, Shan Yibing, Santamaría David, Westover Kenneth D

How does a small molecule bind at a cryptic binding site?

小分子如何与隐蔽的结合位点结合?

Shan, Yibing; Mysore, Venkatesh P; Leffler, Abba E; Kim, Eric T; Sagawa, Shiori; Shaw, David E

A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation

哺乳动物 plexin 调控中同源 RND1 和 RhoD GTP 酶发挥相反作用的假定结构机制

Liu, Yanyan; Ke, Pu; Kuo, Yi-Chun; Wang, Yuxiao; Zhang, Xuewu; Song, Chen; Shan, Yibing

Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations

EGFR/HER3异二聚体的结构分析揭示了HER3激活突变的分子基础

Littlefield, Peter; Liu, Lijun; Mysore, Venkatesh; Shan, Yibing; Shaw, David E; Jura, Natalia

Conformational coupling across the plasma membrane in activation of the EGF receptor

EGF受体激活过程中跨质膜的构象耦合

Endres, Nicholas F; Das, Rahul; Smith, Adam W; Arkhipov, Anton; Kovacs, Erika; Huang, Yongjian; Pelton, Jeffrey G; Shan, Yibing; Shaw, David E; Wemmer, David E; Groves, Jay T; Kuriyan, John

Architecture and membrane interactions of the EGF receptor

EGF受体的结构和膜相互作用

Arkhipov, Anton; Shan, Yibing; Das, Rahul; Endres, Nicholas F; Eastwood, Michael P; Wemmer, David E; Kuriyan, John; Shaw, David E

Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family

Her2激活机制反映了人类EGFR家族中不对称胞外结构域二聚体的进化保守性

Arkhipov, Anton; Shan, Yibing; Kim, Eric T; Dror, Ron O; Shaw, David E

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

JAK2假激酶结构域和致病突变体V617F的晶体结构

Bandaranayake, Rajintha M; Ungureanu, Daniela; Shan, Yibing; Shaw, David E; Silvennoinen, Olli; Hubbard, Stevan R