日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation

糖皮质激素通过抑制H4K12乳酸化作用,提高透明细胞肾细胞癌对HIF-2α抑制剂的敏感性。

Zhang, Kenan; He, Lin; Wang, Yizhou; Qin, Sen; Yu, Chunyu; Zheng, Enrun; Zhang, Zedan; Xu, Yawei; Chen, Xiaolin; Liu, Yanhua; Liu, Xiaoya; Guan, Sudun; Xia, Lu; Suo, Feiya; Pei, Fei; Du, Juan; Su, Yiran; Li, Yanze; Wu, Yu; Zhou, Xuehong; Zhou, Jingcheng; Cai, Lin; Tang, Xinjing; Zhang, Zheng; Shang, Yongfeng; Zhang, Qing; Gong, Kan; Sun, Luyang

CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1.

通过 CRISPR 筛选人类胰腺癌异种移植瘤,发现 KLF5 增殖脆弱性与表观遗传修饰因子 NCAPD2 和 MTHFD1 有关。

Maeda Masahiro, Sherman Kenna, Zhou Weiqiang, Cheng Jiaqi, Nihongaki Yuta, Idrizi Adrian, Tryggvadottir Rakel, Camacho Oscar, Shang Xingbo, Min Jimin, Koldobskiy Michael A, Maitra Anirban, Levchenko Andre, Slusher Barbara S, Ji Hongkai, Feinberg Andrew P

Serotonergic System-Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy.

血清素系统靶向核酸水凝胶协调兴奋性恢复和回路重建,用于脊髓损伤治疗。

Li Chunlin, Zhao Xiaoqing, Jiang Kai, Kang Haixia, Liu Shuo, Jiang Linlin, Bai Baoshuai, Cui Haonan, Zhang Ziyang, Dong Menglei, Zhang Ruizhi, Zou Chenbo, Shang Shenghui, Zhang Chi, Fan Xiangchuang, Zhu Lijuan, Duan Huiquan, Zhang Chuan, Feng Shiqing, Zhou Hengxing

ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.

ADGRG1靶向缺氧预处理的细胞外囊泡通过输送牛磺酸来破坏髓核细胞中氧化应激反馈环驱动的铁死亡,从而改善椎间盘退变。

Chen Shang, Jia Shu, Fan Xutao, Zhu Laimin, Qi Bao, Yan Fenglian, Gao Xu, Zhang Lu, Gao Sheng, Shao Jun, Yang Tao, Li Shudong, Chen Guowu, Xiong Huabao, Li Zongjin, Hao Yanke, Meng Chunyang

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities

人类蛋白聚糖连接区糖基转移酶是二聚体,并表现出意想不到的特异性

Weidler, Sascha; Bundgaard, Ole; Hessefort, Markus; Rädisch, Marisa; Graf, Christopher Günther Franz; Lam, Kevin; Neubauer, Vanessa J; Eisenreich, Johanna; Köhler, Leonhard; Moremen, Kelley W; Steentoft, Catharina; Clausen, Henrik; Huang, Teng-Yi; Hung, Shang-Cheng; Steegborn, Clemens; Weyand, Michael; Unverzagt, Carlo

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.

确定能够逆转具有朊病毒样结构域的 RNA 结合蛋白的有害相变的 RNA 寡核苷酸。

Guo Lin, Mann Jacob R, Mauna Jocelyn C, Copley Katie E, Wang Hejia, Rubien Jack D, Bergmann Cristian A, Carey Jenny L, Merjane Jessica, Ngo Marilyn, Xu Jiazhen, Odeh Hana M, Lin JiaBei, Lee Bo Lim, Ganser Laura, Robinson Emma, Kim Kevin M, Murthy Anastasia C, Paul Tapas, Portz Bede, Gleixner Amanda M, Diaz Zamia, Smirnov Ashleigh, Padilla George, Lavorando Ellen, Espy Carolann, Shang Yulei, Huang Eric J, Chesi Alessandra, Fawzi Nicolas L, Myong Sua, Donnelly Christopher J, Shorter James

Chiglitazar in MASLD with hypertriglyceridemia and insulin resistance: A phase II, randomized, double-blind, placebo-controlled study

奇格列他扎治疗伴有高甘油三酯血症和胰岛素抵抗的MASLD:一项II期随机、双盲、安慰剂对照研究

Sun, Yameng; Wu, Cuisong; Xin, Guijie; Zhong, Bihui; Wu, Xiaofeng; Liu, Yali; Shi, Junping; Zhang, Qin; Zhao, Yingren; Gao, Yufeng; Xin, Yongning; Zhu, Yueyong; Wu, Lixian; Mao, Xiaorong; Du, Jian; Shang, Jia; Sun, Weiwei; Xu, Jie; Yu, Zujiang; Nan, Yuemin; Sheng, Huiping; Li, Yue; Rao, Huiying; Yu, Chaohui; Cao, Haixiang; Chen, Bo; Li, Zhibin; Wu, Xiaoning; Tong, Xiaofei; You, Hong

TCF21 promotes epithelial-to-mesenchymal transition and cytoskeleton reorganization in uterine development and endometriosis

TCF21促进子宫发育和子宫内膜异位症中的上皮间质转化和细胞骨架重组

Zhu, Jingwen; Wu, Peili; Ma, Yilei; Peng, Zijun; Fa, Hangwei; Qin, Leyi; Geng, Mengyang; Lu, Ruihui; Zeng, Cheng; Wu, Ning; Zhang, Deyu; Zhang, Chengying; Peng, Chao; Zhou, Yingfang; Shang, Yongfeng; Liang, Jing; Xue, Qing

CHAMP1 is an essential regulator for human myoblast fusion and muscle development.

CHAMP1 是人类成肌细胞融合和肌肉发育的重要调节因子。

Zhang Haifeng, Zhou Min, Zhang Zheng, Wang Zhaoning, Shi Ruifeng, Wang Yushu, Wei Xiaolin, Shang Renjie, Li Jianwen, He Cuiyu, Xie Jin, Diao Yarui, Bi Pengpeng

Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion.

开发分裂毒素 CRISPR 筛选平台,以系统地鉴定人类成肌细胞融合的调节因子。

Zhang Haifeng, Shang Renjie, Zhang Zheng, Zhou Min, Bigot Anne, Cai Yanqing, Zhao Yanran, Wang Yushu, Deshmukh Aaryahi, Kudryashova Elena, Kudryashov Dmitri S, He Cuiyu, Mouly Vincent, Bi Pengpeng