日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.

MITA/STING 功能获得性突变体中额外的位点突变消除了自身免疫性 SAVI 表型,并指导了治疗策略。

Li Fang-Xu, Liu Sheng, Zhang Zhi-Dong, Shuai Xin, Xiao Bi-Kun, Yang Jia, Lu Defen, Lin Dandan, Shang Guijun, Zhong Bo

Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation

对不同丝状体状态的结构分析揭示了细菌STING激活的调控机制

Yang, Yuchao; Liu, Yueyue; Ma, Xue; Zhao, Xuan; Cao, Jian; Liu, Yu; Li, Shanqin; Wu, Jing; Gao, Yuanzhu; Chen, Lianwan; Wu, Changxin; Shang, Guijun; Liu, Sheng; Lu, Defen

Virus Infection and mRNA Nuclear Export

病毒感染和mRNA核输出

Guo, Jiayin; Zhu, Yaru; Ma, Xiaoya; Shang, Guijun; Liu, Bo; Zhang, Ke

Activation of STING Based on Its Structural Features

基于其结构特征的STING激活

Hussain, Behzad; Xie, Yufeng; Jabeen, Uzma; Lu, Defen; Yang, Bo; Wu, Changxin; Shang, Guijun

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation.

PlexinC1/A39R复合物的冷冻电镜结构揭示了配体诱导激活所必需的域间相互作用

Kuo Yi-Chun, Chen Hua, Shang Guijun, Uchikawa Emiko, Tian Hui, Bai Xiao-Chen, Zhang Xuewu

Crystal structures of porcine STING(CBD)-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins

猪STING(CBD)-CDN复合物的晶体结构揭示了STING蛋白配体识别和区分的机制。

Cong, Xiaoyan; Yuan, Zenglin; Du, Yijun; Wu, Bo; Lu, Defen; Wu, Xiangju; Zhang, Youjia; Li, Feng; Wei, Bin; Li, Jun; Wu, Jiaqiang; Xu, Sujuan; Wang, Jinbao; Qi, Jing; Shang, Guijun; Gu, Lichuan

Crystallization and preliminary X-ray diffraction analysis of the diterpene cyclooctatin synthase (CYC) from Streptomyces sp. LZ35

链霉菌属 LZ35 菌株二萜环辛酸合酶 (CYC) 的结晶和初步 X 射线衍射分析

Zhang, Xiulei; Shang, Guijun; Gu, Lichuan; Shen, Yuemao

Purification, crystallization and preliminary crystallographic analysis of a ribosome-recycling factor from Thermoanaerobacter tengcongensis (TteRRF)

嗜热厌氧菌(Thermoanaerobacter tengcongensis)核糖体回收因子(TteRRF)的纯化、结晶及初步晶体学分析

Shang, Guijun; Feng, Duo; Lu, Fang; Zhang, Hongjie; Cang, Huaixing; Gao, Wei; Bi, Ruchang

Expression, purification and preliminary crystallographic analysis of the T6SS effector protein Tse3 from Pseudomonas aeruginosa

铜绿假单胞菌T6SS效应蛋白Tse3的表达、纯化和初步晶体学分析

Lu, Defen; Shang, Guijun; Yu, Qian; Zhang, Heqiao; Zhao, Yanyu; Cang, Huaixing; Gu, Lichuan; Xu, Sujuan; Huang, Yan

Crystallization and preliminary crystallographic analysis of a calcineurin B-like protein 1 (CBL1) mutant from Ammopiptanthus mongolicus

对来自蒙古沙蚕(Ammopiptanthus mongolicus)的钙调磷酸酶B样蛋白1(CBL1)突变体进行结晶和初步晶体学分析

Shang, Guijun; Cang, Huaixing; Liu, Zhijie; Gao, Wei; Bi, Ruchang