日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation

糖皮质激素通过抑制H4K12乳酸化作用，提高透明细胞肾细胞癌对HIF-2α抑制剂的敏感性。

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-026-02622-7
Zhang, Kenan; He, Lin; Wang, Yizhou; Qin, Sen; Yu, Chunyu; Zheng, Enrun; Zhang, Zedan; Xu, Yawei; Chen, Xiaolin; Liu, Yanhua; Liu, Xiaoya; Guan, Sudun; Xia, Lu; Suo, Feiya; Pei, Fei; Du, Juan; Su, Yiran; Li, Yanze; Wu, Yu; Zhou, Xuehong; Zhou, Jingcheng; Cai, Lin; Tang, Xinjing; Zhang, Zheng; Shang, Yongfeng; Zhang, Qing; Gong, Kan; Sun, Luyang
肿瘤
肿瘤免疫
肾癌
乳酸化
细胞生物学
免疫/内分泌
发表日期：2026
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TCF21 promotes epithelial-to-mesenchymal transition and cytoskeleton reorganization in uterine development and endometriosis

TCF21促进子宫发育和子宫内膜异位症中的上皮间质转化和细胞骨架重组

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69551-5
Zhu, Jingwen; Wu, Peili; Ma, Yilei; Peng, Zijun; Fa, Hangwei; Qin, Leyi; Geng, Mengyang; Lu, Ruihui; Zeng, Cheng; Wu, Ning; Zhang, Deyu; Zhang, Chengying; Peng, Chao; Zhou, Yingfang; Shang, Yongfeng; Liang, Jing; Xue, Qing
细胞生物学
发育与干细胞
上皮间质转化
发表日期：2026
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Correction: LSD1 is required for euchromatic origin firing and replication timing

更正：LSD1 是常染色质起始点激活和复制时序所必需的

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-025-02203-0
Wang, Yue; Huang, Yunchao; Cheng, Edith; Liu, Xinhua; Zhang, Yu; Yang, Jianguo; Young, Jordan T F; Brown, Grant W; Yang, Xiaohan; Shang, Yongfeng
LSD1
发表日期：2025
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A CMTM6 Nanobody Overcomes EGFR-TKI Resistance in Non-Small Cell Lung Cancer.

CMTM6纳米抗体克服了非小细胞肺癌的EGFR-TKI耐药性

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202410945
Xia Lu, Wang Jichuan, Xue Hui, Li Haimeng, Li Qinghua, Qin Sen, Yu Chunyu, Liu Yanhua, Gao Yu, Li Lingyun, Guan Sudun, Zheng Enrun, Suo Feiya, He Lin, Wang Yongsheng, Han Wenling, Shang Yongfeng, Geng Yong, Sun Luyang
细胞生物学
肺癌
EGFR
发表日期：2025
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Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT).

人类肌酸转运蛋白 (hCRT) 的底物吸收和抑制的结构见解。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2426135122
Yuan Xinyi, Yin Jian, Liu Chang, Chen Xudong, Chen Meiying, Wang Yixue, Yang Zi, Wang Yue, Jiang Li, Zhou Niyun, Wang Xiaojuan, Liu Botong, Ma Zhaoqi, Wang Kaiyan, Li Hongen, Zhang Sensen, Shang Yongfeng, Yang Maojun
发表日期：2025
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BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer

BRD4 指导的超级增强子转录抑制程序组织与乳腺癌化疗疗效相关

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2109133119
Liu, Beibei; Liu, Xinhua; Han, Lulu; Chen, Xing; Wu, Xiaodi; Wu, Jiajing; Yan, Dong; Wang, Yue; Liu, Shumeng; Shan, Lin; Zhang, Yu; Shang, Yongfeng
BRD4
肿瘤
肿瘤免疫
乳腺癌
发表日期：2022
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Corrigendum: Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5

更正：泛素连接酶RNF20/40通过稳定运动蛋白Eg5促进纺锤体组装并促进乳腺癌发生。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/ncomms13462
Duan, Yang; Huo, Dawei; Gao, Jie; Wu, Heng; Ye, Zheng; Liu, Zhe; Zhang, Kai; Shan, Lin; Zhou, Xing; Wang, Yue; Su, Dongxue; Ding, Xiang; Shi, Lei; Wang, Yan; Shang, Yongfeng; Xuan, Chenghao
RNF20
肿瘤
肿瘤免疫
乳腺癌
发表日期：2016
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Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis

USP7 稳定组蛋白去甲基化酶 PHF8 可促进乳腺癌发生

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI85747
Wang, Qian; Ma, Shuai; Song, Nan; Li, Xin; Liu, Ling; Yang, Shangda; Ding, Xiang; Shan, Lin; Zhou, Xing; Su, Dongxue; Wang, Yue; Zhang, Qi; Liu, Xinhua; Yu, Na; Zhang, Kai; Shang, Yongfeng; Yao, Zhi; Shi, Lei
PHF8
肿瘤
表观遗传
肿瘤免疫
乳腺癌
SP7
发表日期：2016
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SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer

SCF(JFK) 是 ING4 的真正 E3 连接酶，也是乳腺癌血管生成和转移的强效促进因子。

期刊:Genes & Development
影响因子:7.7
doi:10.1101/gad.254292.114
Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng; Sun, Luyang; Shang, Yongfeng
肿瘤
肿瘤免疫
乳腺癌
SCF
血管生成
发表日期：2015
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SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

SET8促进上皮-间质转化，并赋予TWIST双重转录活性

期刊:EMBO Journal
影响因子:8.3
doi:10.1038/emboj.2011.364
Yang, Fen; Sun, Luyang; Li, Qian; Han, Xiao; Lei, Liandi; Zhang, Hua; Shang, Yongfeng
SET
发表日期：2012
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