日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A potent Lassa virus antiviral targets an arenavirus virulence determinant

一种强效的拉沙病毒抗病毒药物靶向沙粒病毒的毒力决定因子。

Madu, Ikenna G; Files, Megan; Gharaibeh, Dima N; Moore, Amy L; Jung, Kie-Hoon; Gowen, Brian B; Dai, Dongcheng; Jones, Kevin F; Tyavanagimatt, Shanthakumar R; Burgeson, James R; Korth, Marcus J; Bedard, Kristin M; Iadonato, Shawn P; Amberg, Sean M

Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans

利用药代动力学和药效学模型确定ST-246在人体中预防天花感染的剂量

Leeds, Janet M; Fenneteau, Frederique; Gosselin, Nathalie H; Mouksassi, Mohamad-Samer; Kassir, Nastya; Marier, J F; Chen, Yali; Grosenbach, Doug; Frimm, Annie E; Honeychurch, Kady M; Chinsangaram, Jarasvech; Tyavanagimatt, Shanthakumar R; Hruby, Dennis E; Jordan, Robert

Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers

在人体志愿者中,每日单次口服抗正痘病毒化合物ST-246,连续14天,其安全性和药代动力学研究

Chinsangaram, Jarasvech; Honeychurch, Kady M; Tyavanagimatt, Shanthakumar R; Leeds, Janet M; Bolken, Tove' C; Jones, Kevin F; Jordan, Robert; Marbury, Thomas; Ruckle, Jon; Mee-Lee, Denis; Ross, Eric; Lichtenstein, Israel; Pickens, Margaret; Corrado, Michael; Clarke, Jean M; Frimm, Annie M; Hruby, Dennis E

Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers

在人体志愿者中比较单次口服抗正痘病毒化合物ST-246的多晶型i型胶囊与V型胶囊的药代动力学

Chinsangaram, Jarasvech; Honeychurch, Kady M; Tyavanagimatt, Shanthakumar R; Bolken, Tove' C; Jordan, Robert; Jones, Kevin F; Marbury, Thomas; Lichtenstein, Israel; Pickens, Margaret; Corrado, Michael; Landis, Patrick; Clarke, Jean M; Frimm, Annie M; Hruby, Dennis E

Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

比较小鼠、兔和猴静脉输注或口服ST-246®后的安全性和药代动力学

Chen, Yali; Amantana, Adams; Tyavanagimatt, Shanthakumar R; Zima, Daniela; Yan, X Steven; Kasi, Gopi; Weeks, Morgan; Stone, Melialani A; Weimers, William C; Samuel, Peter; Tan, Ying; Jones, Kevin F; Lee, Daniel R; Kickner, Shirley S; Saville, Bradley M; Lauzon, Martin; McIntyre, Alan; Honeychurch, Kady M; Jordan, Robert; Hruby, Dennis E; Leeds, Janet M

Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects

健康成年受试者重复口服抗正痘病毒化合物ST-246后的安全性和药代动力学

Jordan, Robert; Chinsangaram, Jarasvech; Bolken, Tove' C; Tyavanagimatt, Shanthakumar R; Tien, Deborah; Jones, Kevin F; Frimm, Annie; Corrado, Michael L; Pickens, Margaret; Landis, Patrick; Clarke, Jean; Marbury, Thomas C; Hruby, Dennis E

Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor

新型正痘病毒逸出抑制剂ST-246的单剂量安全性和药代动力学研究

Jordan, Robert; Tien, Deborah; Bolken, Tove' C; Jones, Kevin F; Tyavanagimatt, Shanthakumar R; Strasser, Josef; Frimm, Annie; Corrado, Michael L; Strome, Phoebe G; Hruby, Dennis E