ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.
ADGRG1靶向缺氧预处理的细胞外囊泡通过输送牛磺酸来破坏髓核细胞中氧化应激反馈环驱动的铁死亡，从而改善椎间盘退变。
期刊:Bioactive Materials
影响因子:20.3
doi:10.1016/j.bioactmat.2026.02.029
Chen Shang, Jia Shu, Fan Xutao, Zhu Laimin, Qi Bao, Yan Fenglian, Gao Xu, Zhang Lu, Gao Sheng, Shao Jun, Yang Tao, Li Shudong, Chen Guowu, Xiong Huabao, Li Zongjin, Hao Yanke, Meng Chunyang
