Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
唐氏综合征中与阿尔茨海默病相关的内体功能障碍与 Abeta 无关,但需要 APP,并且可通过 BACE-1 抑制逆转
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.0908953107
Ying Jiang, Kerry A Mullaney, Corrinne M Peterhoff, Shaoli Che, Stephen D Schmidt, Anne Boyer-Boiteau, Stephen D Ginsberg, Anne M Cataldo, Paul M Mathews, Ralph A Nixon