日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism

骨骼肌 iPLA2γ 基因缺失会导致线粒体功能障碍、肌肉萎缩和全身能量代谢改变

Sung Ho Moon, Beverly Gibson Dilthey, Shaoping Guan, Harold F Sims, Sara K Pittman, Amy L Keith, Christopher M Jenkins, Conrad C Weihl, Richard W Gross

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout

12-LOX 催化血小板中 2-花生四烯酰溶菌脂的氧化,生成因 iPLA2γ 敲除而减弱的二十烷酸溶菌脂

Xinping Liu, Harold F Sims, Christopher M Jenkins, Shaoping Guan, Beverly G Dilthey, Richard W Gross

Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2-15-HETE lysophospholipids

sn-1 酰基转移酶利用 2-15-HETE 溶血磷脂合成氧化磷脂

Gao-Yuan Liu, Sung Ho Moon, Christopher M Jenkins, Harold F Sims, Shaoping Guan, Richard W Gross

The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

磷脂酶 iPLA2γ 是一种主要介质,可从心磷脂中释放氧化脂肪链,整合线粒体生物能量学和信号传导

Gao-Yuan Liu, Sung Ho Moon, Christopher M Jenkins, Maoyin Li, Harold F Sims, Shaoping Guan, Richard W Gross

Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size

心肌细胞特异性敲除钙非依赖性磷脂酶 A2γ (iPLA2γ) 可减少缺血/再灌注期间的氧化脂肪酸并减少梗塞面积

Sung Ho Moon, David J Mancuso, Harold F Sims, Xinping Liu, Annie L Nguyen, Kui Yang, Shaoping Guan, Beverly Gibson Dilthey, Christopher M Jenkins, Carla J Weinheimer, Attila Kovacs, Dana Abendschein, Richard W Gross

Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation

通过电荷转换衍生化、选择反应监测和精确质量定量分析氧化脂肪酸

Xinping Liu, Sung Ho Moon, David J Mancuso, Christopher M Jenkins, Shaoping Guan, Harold F Sims, Richard W Gross

Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids

二价阳离子激活线粒体钙非依赖性磷脂酶 A2γ (iPLA2γ),介导花生四烯酸释放和下游二十烷酸的产生

Sung Ho Moon, Christopher M Jenkins, Xinping Liu, Shaoping Guan, David J Mancuso, Richard W Gross

Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency

心肌通过心磷脂合酶调节脂质组学通量:为生物能量效率设定节拍

Michael A Kiebish, Kui Yang, Harold F Sims, Christopher M Jenkins, Xinping Liu, David J Mancuso, Zhongdan Zhao, Shaoping Guan, Dana R Abendschein, Xianlin Han, Richard W Gross

Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation

钙非依赖性磷脂酶 A2gamma 的基因消融可通过线粒体解偶联和增加脂肪细胞脂肪酸氧化来预防高脂饮食期间的肥胖和胰岛素抵抗

David J Mancuso, Harold F Sims, Kui Yang, Michael A Kiebish, Xiong Su, Christopher M Jenkins, Shaoping Guan, Sung Ho Moon, Terri Pietka, Fatiha Nassir, Timothy Schappe, Kristin Moore, Xianlin Han, Nada A Abumrad, Richard W Gross

Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction

钙依赖性磷脂酶 A2{gamma} 的基因消融导致海马心磷脂含量和分子种类分布发生改变、线粒体变性、自噬和认知功能障碍

David J Mancuso, Paul Kotzbauer, David F Wozniak, Harold F Sims, Christopher M Jenkins, Shaoping Guan, Xianlin Han, Kui Yang, Gang Sun, Ibrahim Malik, Sara Conyers, Karen G Green, Robert E Schmidt, Richard W Gross