日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of chemotherapy agents in breast cancer.

FGD3 介导细胞溶解性死亡,增强化疗药物在乳腺癌中的疗效和免疫原性。

Zhu Junyao, Dai Xinyi, Ghosh Santanu, Wei Elaine, Mao Chengjian, Jiang Qianjin, Spaulding Abigail J, Mulligan Michael P, Romero Roger, Han Yoo Jane, Boudreau Matthew W, Olopade Olufunmilayo, Hergenrother Paul J, Shapiro David J

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice

单次注射小分子药物可使小鼠体内大型乳腺肿瘤完全消退

Mulligan, Michael P; Boudreau, Matthew W; Bouwens, Brooke A; Lee, Yoongyeong; Carrell, Hunter W; Zhu, Junyao; Mousses, Spyro; Shapiro, David J; Nelson, Erik R; Fan, Timothy M; Hergenrother, Paul J

A necrosis inducer promotes an immunogenic response and destroys ovarian cancers in mouse xenografts and patient ascites organoids.

坏死诱导剂可促进免疫反应,并破坏小鼠异种移植和患者腹水类器官中的卵巢癌

Duraki Darjan, Jabeen Musarrat, Mao Chengjian, Wang Lawrence, Ghosh Santanu, Dai Xinyi, Zhu Junyao, Boudreau Matthew W, Nelson Erik R, Hergenrother Paul J, Cheng Georgina, Shapiro David J

Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization

通过光遗传学诱导RIPK3寡聚化实现炎症溶解细胞死亡的时空控制

Oh, Teak-Jung; Krishnamurthy, Vishnu; Han, Jeong Won; Zhu, Junyao; Beg, Zayn; Mehfooz, Amna; Gworek, Bryan; Shapiro, David J; Zhang, Kai

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

一种小分子未折叠蛋白反应激活剂可根除小鼠体内的人类乳腺肿瘤。

Boudreau, Matthew W; Duraki, Darjan; Wang, Lawrence; Mao, Chengjian; Kim, Ji Eun; Henn, Madeline A; Tang, Bingtao; Fanning, Sean W; Kiefer, Jeffrey; Tarasow, Theodore M; Bruckheimer, Elizabeth M; Moreno, Ramon; Mousses, Spyro; Greene, Geoffrey L; Roy, Edward J; Park, Ben Ho; Fan, Timothy M; Nelson, Erik R; Hergenrother, Paul J; Shapiro, David J

Protein kinase C-α is upregulated by IMP1 in melanoma and is linked to poor survival.

在黑色素瘤中,蛋白激酶 C-α 受 IMP1 上调,且与生存率低有关

Mahapatra Lily, Andruska Neal, Mao Chengjian, Gruber Stephen B, Johnson Timothy M, Fullen Douglass R, Raskin Leon, Shapiro David J

RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade

RAS-MAPK 再激活促进了 FGFR1 扩增肺癌的获得性耐药性,并为前期 FGFR-MEK 阻断提供了理论基础

Bruno Bockorny #, Maria Rusan #, Wankun Chen, Rachel G Liao, Yvonne Li, Federica Piccioni, Jun Wang, Li Tan, Aaron R Thorner, Tianxia Li, Yanxi Zhang, Changhong Miao, Therese Ovesen, Geoffrey I Shapiro, David J Kwiatkowski, Nathanael S Gray, Matthew Meyerson, Peter S Hammerman, Adam J Bass

A New Role for Estrogen Receptor α in Cell Proliferation and Cancer: Activating the Anticipatory Unfolded Protein Response

雌激素受体α在细胞增殖和癌症中的新作用:激活预期性未折叠蛋白反应

Livezey, Mara; Kim, Ji Eun; Shapiro, David J

Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells

雌激素受体α和芳烃受体参与植物雌激素在靶细胞中的作用

Gong, Ping; Madak-Erdogan, Zeynep; Flaws, Jodi A; Shapiro, David J; Katzenellenbogen, John A; Katzenellenbogen, Benita S

Anticipatory activation of the unfolded protein response by epidermal growth factor is required for immediate early gene expression and cell proliferation.

表皮生长因子对未折叠蛋白反应的预先激活是早期基因表达和细胞增殖所必需的

Yu Liqun, Andruska Neal, Zheng Xiaobin, Shapiro David J