日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Measurement of Centanafadine Concentrations in a Pharmacokinetic Trial: Comparison of Traditional Venipuncture Versus Blood Microsampling

在药代动力学试验中测定氯萘法定浓度：传统静脉穿刺法与血液微量采样法的比较

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.70470
Roth, Sharin E; Westcott-Baker, Lucas; Wang, Yanlin; Chung, Chris
发表日期：2026
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Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development

下一代药物性肝损伤生物标志物：生物标志物鉴定优先级排序及药物研发中生物样本采集最佳实践

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.1571
Roth, Sharin E; Avigan, Mark I; Bourdet, David; Brott, David; Church, Rachel; Dash, Ajit; Keller, Douglas; Sherratt, Philip; Watkins, Paul B; Westcott-Baker, Lucas; Lentini, Silvia; Merz, Michael; Ramaiah, Lila; Ramaiah, Shashi K; Stanley, Ann Marie; Marcinak, John
肝损伤
毒理研究
发表日期：2020
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Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease

托伐普坦及其部分代谢物在啮齿类多囊肾模型中的肝胆分布发生改变

期刊:Drug Metabolism and Disposition
影响因子:4.4
doi:10.1124/dmd.118.083907
James J Beaudoin, Jacqueline Bezençon, Yanguang Cao, Katsuhiko Mizuno, Sharin E Roth, William J Brock, Kim L R Brouwer
代谢
发表日期：2019
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Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease

多囊肾病啮齿动物模型中肝脏转运蛋白的表达和功能改变

期刊:Drug Metabolism and Disposition
影响因子:4.4
doi:10.1124/dmd.119.086785
Jacqueline Bezençon, James J Beaudoin, Katsuaki Ito, Dong Fu, Sharin E Roth, William J Brock, Kim L R Brouwer
信号转导
IHC
Goat
IgG Fc
发表日期：2019
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miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

在原代人肝细胞微图案共培养模型中，外泌体中 miR-122 的释放先于托伐普坦诱导的明显坏死

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfx206
Mosedale Merrie, Eaddy J Scott, Trask O Joseph Jr, Holman Natalie S, Wolf Kristina K, LeCluyse Edward, Ware Brenton R, Khetani Salman R, Lu Jingtao, Brock William J, Roth Sharin E, Watkins Paul B
细胞生物学
Human
外泌体
发表日期：2018
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Bile Acids as Potential Biomarkers to Assess Liver Impairment in Polycystic Kidney Disease

胆汁酸作为评估多囊肾病肝功能损害的潜在生物标志物

期刊:International Journal of Toxicology
影响因子:1
doi:10.1177/1091581818760746
Brock, William J; Beaudoin, James J; Slizgi, Jason R; Su, Mingming; Jia, Wei; Roth, Sharin E; Brouwer, Kim L R
发表日期：2018
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Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach

编辑推荐：采用跨学科合作方法识别托伐普坦诱导肝损伤的候选风险因素和机制

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfw269
Mosedale, Merrie; Kim, Yunjung; Brock, William J; Roth, Sharin E; Wiltshire, Tim; Eaddy, J Scott; Keele, Gregory R; Corty, Robert W; Xie, Yuying; Valdar, William; Watkins, Paul B
肝损伤
毒理研究
发表日期：2017
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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

应用机制模型评估托伐普坦药物引起肝损伤的可能机制并识别患者易感因素

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfw193
Woodhead, Jeffrey L; Brock, William J; Roth, Sharin E; Shoaf, Susan E; Brouwer, Kim L R; Church, Rachel; Grammatopoulos, Tom N; Stiles, Linsey; Siler, Scott Q; Howell, Brett A; Mosedale, Merrie; Watkins, Paul B; Shoda, Lisl K M
肝损伤
毒理研究
发表日期：2017
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