Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy
新型亲电酰胺可通过 Ugi 反应干扰硫氧还蛋白系统,通过抑制硫氧还蛋白还原酶 1 (TrxR1) 实现:鉴定 DVD-445 作为抗癌治疗的新先导化合物
期刊:European Journal of Medicinal Chemistry
影响因子:6
doi:10.1016/j.ejmech.2019.111580
Mirna Jovanović, Daniil Zhukovsky, Ana Podolski-Renić, Ilona Domračeva, Raivis Žalubovskis, Milan Senćanski, Sanja Glišić, Vladimir Sharoyko, Tatiana Tennikova, Dmitry Dar'in, Milica Pešić, Mikhail Krasavin