日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

HSF1通路抑制剂临床候选药物(CCT361814/NXP800)基于表型筛选开发,有望用于治疗难治性卵巢癌和其他恶性肿瘤。

Pasqua, A Elisa; Sharp, Swee Y; Chessum, Nicola E A; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E; Rye, Carl S; Mok, N Yi; Liu, Manjuan; Henley, Alan T; Gowan, Sharon; De Billy, Emmanuel; Te Poele, Robert; Powers, Marissa; Eccles, Suzanne A; Clarke, Paul A; Raynaud, Florence I; Workman, Paul; Jones, Keith; Cheeseman, Matthew D

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

发现 4,6-二取代嘧啶类化合物是热休克因子 1 (HSF1) 应激通路和 CDK9 的有效抑制剂

Rye, Carl S; Chessum, Nicola E A; Lamont, Scott; Pike, Kurt G; Faulder, Paul; Demeritt, Julie; Kemmitt, Paul; Tucker, Julie; Zani, Lorenzo; Cheeseman, Matthew D; Isaac, Rosie; Goodwin, Louise; Boros, Joanna; Raynaud, Florence; Hayes, Angela; Henley, Alan T; de Billy, Emmanuel; Lynch, Christopher J; Sharp, Swee Y; Te Poele, Robert; Fee, Lisa O'; Foote, Kevin M; Green, Stephen; Workman, Paul; Jones, Keith

Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.

对新型 HSP90 抑制剂 NVP-AUY922 在成人和儿童胶质母细胞瘤中的机制评价

Gaspar Nathalie, Sharp Swee Y, Eccles Suzanne A, Gowan Sharon, Popov Sergey, Jones Chris, Pearson Andrew, Vassal Gilles, Workman Paul