日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression.

DNA错配修复蛋白MSH6是PD-L1表达的一种新型调节因子

Brooksbank Kirsten, Smith Charlotte, Maniati Eleni, Gibson Amy, Tse Wai Yiu, Hall Amy Kate, Wang Jun, Sharp Tyson V, Martin Sarah A

C-terminal tagging impairs AGO2 function.

C 端标记会损害 AGO2 功能

Shah Kunal M, Crozier Alex F F, Assaraf Anika, Arya Muzjda, Grevitt Paul, Mardakheh Faraz, Plevin Michael J, Sharp Tyson V

Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

支气管上皮细胞寿命延长可维持正常的细胞表型和转录组完整性

O'Loughlin, Jonathan; Hall, Robert J; Bhaker, Sangita; Portelli, Michael A; Henry, Amanda; Pang, Vincent; Bates, David O; Sharp, Tyson V; Sayers, Ian

Oncometabolite induced primary cilia loss in pheochromocytoma

嗜铬细胞瘤中癌代谢物诱导的原发性纤毛丢失

O'Toole, Samuel M; Watson, David S; Novoselova, Tatiana V; Romano, Lisa E L; King, Peter J; Bradshaw, Teisha Y; Thompson, Clare L; Knight, Martin M; Sharp, Tyson V; Barnes, Michael R; Srirangalingam, Umasuthan; Drake, William M; Chapple, J Paul

LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death

LIMD1受LMP1信号通路诱导并参与其中,能够保护EBV转化细胞免受DNA损伤诱导的细胞死亡。

Wang, Ling; Howell, Mary E A; McPeak, Brooke; Riggs, Katrina; Kohne, Carissa; Yohanon, Jether Uel; Foxler, Daniel E; Sharp, Tyson V; Moorman, Jonathan P; Yao, Zhi Q; Ning, Shunbin

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

Argonaute蛋白在miRNA沉默中的利用取决于LIM结构域蛋白的磷酸化依赖性募集

Bridge, Katherine S; Shah, Kunal M; Li, Yigen; Foxler, Daniel E; Wong, Sybil C K; Miller, Duncan C; Davidson, Kathryn M; Foster, John G; Rose, Ruth; Hodgkinson, Michael R; Ribeiro, Paulo S; Aboobaker, A Aziz; Yashiro, Kenta; Wang, Xiaozhong; Graves, Paul R; Plevin, Michael J; Lagos, Dimitris; Sharp, Tyson V

BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity

BMI-1可延长人支气管上皮细胞的增殖潜能,同时保留其黏液纤毛分化能力。

Munye, Mustafa M; Shoemark, Amelia; Hirst, Robert A; Delhove, Juliette M; Sharp, Tyson V; McKay, Tristan R; O'Callaghan, Christopher; Baines, Deborah L; Howe, Steven J; Hart, Stephen L

Ajmaline blocks I(Na) and I(Kr) without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters

阿义马林阻断 I(Na) 和 I(Kr),但未引起布鲁加达综合征患者和对照组人类多能干细胞衍生的心脏细胞簇之间的差异。

Miller, Duncan C; Harmer, Stephen C; Poliandri, Ariel; Nobles, Muriel; Edwards, Elizabeth C; Ware, James S; Sharp, Tyson V; McKay, Tristan R; Dunkel, Leo; Lambiase, Pier D; Tinker, Andrew

Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells

miR-132对AGO2的抑制是人原代内皮细胞中miRNA介导的基因沉默的决定因素

Leonov, German; Shah, Kunal; Yee, Daniel; Timmis, Jon; Sharp, Tyson V; Lagos, Dimitris

Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition

将靶向囊泡谷氨酸转运蛋白1 (VGLUT1) 的短发夹RNA载体通过慢病毒递送至小鼠海马体,会损害其认知能力。

King, Madeleine V; Kurian, Nisha; Qin, Si; Papadopoulou, Nektaria; Westerink, Ben H C; Cremers, Thomas I; Epping-Jordan, Mark P; Le Poul, Emmanuel; Ray, David E; Fone, Kevin C F; Kendall, David A; Marsden, Charles A; Sharp, Tyson V