日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613

利用一流的抗癌线粒体药物 CPI-613 靶向癌症分解代谢的新颖、有效方法的证据

Moises O Guardado Rivas, Shawn D Stuart, Daniel Thach, Michael Dahan, Robert Shorr, Zuzana Zachar, Paul M Bingham

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process

一种经过精心设计的小分子通过氧化还原过程攻击肿瘤细胞中的α-酮戊二酸脱氢酶

Shawn D Stuart, Alexandra Schauble, Sunita Gupta, Adam D Kennedy, Brian R Keppler, Paul M Bingham, Zuzana Zachar

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

非氧化还原活性的硫辛酸衍生物会破坏癌细胞线粒体代谢,是体内有效的抗癌剂

Zuzana Zachar, James Marecek, Claudia Maturo, Sunita Gupta, Shawn D Stuart, Katy Howell, Alexandra Schauble, Joanna Lem, Arin Piramzadian, Sameer Karnik, King Lee, Robert Rodriguez, Robert Shorr, Paul M Bingham