日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bacterial genome-wide association study substantiates papGII of Escherichia coli as a major risk factor for urosepsis

细菌全基因组关联研究证实大肠杆菌的papGII是尿脓毒症的主要风险因素

Cuénod, Aline; Agnetti, Jessica; Seth-Smith, Helena M B; Roloff, Tim; Wälchli, Denise; Shcherbakov, Dimitri; Akbergenov, Rashid; Tschudin-Sutter, Sarah; Bassetti, Stefano; Siegemund, Martin; Nickel, Christian H; Moran-Gilad, Jacob; Keys, Timothy G; Pflüger, Valentin; Thomson, Nicholas R; Egli, Adrian

Mitochondrial Mistranslation in Brain Provokes a Metabolic Response Which Mitigates the Age-Associated Decline in Mitochondrial Gene Expression

脑内线粒体翻译错误引发代谢反应,从而减轻与年龄相关的线粒体基因表达下降

Shcherbakov, Dimitri; Juskeviciene, Reda; Cortés Sanchón, Adrián; Brilkova, Margarita; Rehrauer, Hubert; Laczko, Endre; Böttger, Erik C

Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.

Apralogs:Apramycin 5-O-糖苷和醚,具有改进的抗菌活性和核糖体选择性,并降低了对氨酰转移酶(3)-IV 耐药决定簇的敏感性

Quirke Jonathan C K, Rajasekaran Parasuraman, Sarpe Vikram A, Sonousi Amr, Osinnii Ivan, Gysin Marina, Haldimann Klara, Fang Qiao-Jun, Shcherbakov Dimitri, Hobbie Sven N, Sha Su-Hua, Schacht Jochen, Vasella Andrea, Böttger Erik C, Crich David

Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens

丙吡拉霉素的设计、多克级合成、体外和体内评价:一种用于治疗耐药肠杆菌科细菌和其他革兰氏阴性病原体的半合成4,5-脱氧链霉胺类氨基糖苷

Matsushita, Takahiko; Sati, Girish C; Kondasinghe, Nuwan; Pirrone, Michael G; Kato, Takayuki; Waduge, Prabuddha; Kumar, Harshitha Santhosh; Sanchon, Adrian Cortes; Dobosz-Bartoszek, Malgorzata; Shcherbakov, Dimitri; Juhas, Mario; Hobbie, Sven N; Schrepfer, Thomas; Chow, Christine S; Polikanov, Yury S; Schacht, Jochen; Vasella, Andrea; Böttger, Erik C; Crich, David

Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives

奈替米星4'-衍生物的合成、核糖体选择性和抗菌活性

Sonousi, Amr; Shcherbakov, Dimitri; Vasella, Andrea; Böttger, Erik C; Crich, David

Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics

鉴定和评价改良的4'-O-(烷基)4,5-二取代2-脱氧链霉胺类化合物作为下一代氨基糖苷类抗生素

Duscha, Stefan; Boukari, Heithem; Shcherbakov, Dimitri; Salian, Sumantha; Silva, Sandrina; Kendall, Ann; Kato, Takayuki; Akbergenov, Rashid; Perez-Fernandez, Deborah; Bernet, Bruno; Vaddi, Swapna; Thommes, Pia; Schacht, Jochen; Crich, David; Vasella, Andrea; Böttger, Erik C

Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis

细菌rRNA的系统发育序列变异会影响物种对靶向蛋白质合成药物的特异性敏感性。

Akshay, Subramanian; Bertea, Mihai; Hobbie, Sven N; Oettinghaus, Björn; Shcherbakov, Dimitri; Böttger, Erik C; Akbergenov, Rashid