日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Designing allosteric modulators to change GPCR G protein subtype selectivity

设计变构调节剂以改变GPCR G蛋白亚型选择性

Moore, Madelyn N; Person, Kelsey L; Robleto, Valeria L; Alwin, Abigail R; Krusemark, Campbell L; Foster, Noah; Ray, Caroline; Inoue, Asuka; Jackson, Michael R; Sheedlo, Michael J; Barak, Lawrence S; Marron Fernandez de Velasco, Ezequiel; Olson, Steven H; Slosky, Lauren M

The N-terminus of the Clostridioides difficile transferase A component directs toxin activity and potency

艰难梭菌转移酶A组分的N端决定毒素的活性和效力。

Mullard, Robin M; Sheedlo, Michael J

Architectural asymmetry enables DNA transport through the Helicobacter pylori cag type IV secretion system

结构不对称使 DNA 能够通过幽门螺杆菌 CAG IV 型分泌系统进行运输

Mackenzie E Ryan, Prashant P Damke, Caitlynn Bryant, Michael J Sheedlo, Carrie L Shaffer

Molecular architecture of bacterial type IV secretion systems

细菌IV型分泌系统的分子结构

Sheedlo, Michael J; Ohi, Melanie D; Lacy, D Borden; Cover, Timothy L

Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA

细菌去泛素酶SdeA催化水解过程中泛素产物释放的深入研究

Sheedlo, Michael J; Kenny, Sebastian; Podkorytov, Ivan S; Brown, Kwame; Ma, Jia; Iyer, Shalini; Hewitt, Chad S; Arbough, Trent; Mikhailovskii, Oleg; Flaherty, Daniel P; Wilson, Mark A; Skrynnikov, Nikolai R; Das, Chittaranjan

Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.

从前孔到孔的转变的结构见解

Anderson David M, Sheedlo Michael J, Jensen Jaime L, Lacy D Borden

Structural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzyme

艰难梭菌转移酶毒素的结构解析揭示了该酶的单一位点结合模式

Sheedlo, Michael J; Anderson, David M; Thomas, Audrey K; Lacy, D Borden

Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex

嗜肺军团菌Dot/Icm IV型分泌系统核心复合物的结构分析

Clarissa L Durie #, Michael J Sheedlo #, Jeong Min Chung, Brenda G Byrne, Min Su, Thomas Knight, Michele Swanson, D Borden Lacy, Melanie D Ohi

Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

冷冻电镜揭示了幽门螺杆菌Cag IV型分泌系统核心复合物中的物种特异性组分

Sheedlo, Michael J; Chung, Jeong Min; Sawhney, Neha; Durie, Clarissa L; Cover, Timothy L; Ohi, Melanie D; Lacy, D Borden

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

艰难梭菌感染通过 TcdB 损害结肠干细胞,损害上皮修复和疾病恢复

Steven J Mileto, Thierry Jardé, Kevin O Childress, Jaime L Jensen, Ashleigh P Rogers, Genevieve Kerr, Melanie L Hutton, Michael J Sheedlo, Sarah C Bloch, John A Shupe, Katja Horvay, Tracey Flores, Rebekah Engel, Simon Wilkins, Paul J McMurrick, D Borden Lacy, Helen E Abud, Dena Lyras