日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

HSV-1解旋酶-引物酶抑制和复制叉复合物组装的机制

Yu, Zishuo; Sathyanarayana, Pradeep; Liu, Cong; Tan, Joel M J; Yang, Pan; Das, Biswajit; Hu, Side; Fan, Xiaoyi; Ji, Chenggong; Weller, Sandra K; Shekhar, Mrinal; Coen, Donald M; Kranzusch, Philip J; Loparo, Joseph J; Abraham, Jonathan

Proximity-Induced Rewiring of Oncogenic Kinase Triggers Apoptosis

邻近诱导的致癌激酶重编程触发细胞凋亡

Merz, Manuel L; Shoba, Veronika M; Pergu, Rajaiah; Severance, Zachary C; Munkanatta Godage, Dhanushka N P; Deb, Arghya; Kwok, Hui Si; Singh, Prashant; Singh, Sameek; Allen, Jonathan B; Tian, Wenzhi; Gosavi, Pallavi M; Chaudhary, Santosh K; Anokhina, Viktoriya; Weisberg, Ellen L; Payne, N Connor; He, Yao; Dhaliwal, Rohil; Osadchey, Reilly; Shekhar, Mrinal; Mazitschek, Ralph; Rees, Matthew G; Roth, Jennifer A; Cui, Qiang; Griffin, James D; Liau, Brian B; Choudhary, Amit

Early-Enrichment Hit Discovery via Reversible-Work c(t) Estimation in Metadynamics (CTMD)

基于元动力学中可逆功 c(t) 估计的早期富集先导化合物发现 (CTMD)

Adury, Venkata Sai Sreyas; Tiwary, Pratyush; Gu, Xinyu; Shekhar, Mrinal

Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World

利用化学结构进行毒性预测的机器学习:现实世界成功的基石

Seal, Srijit; Mahale, Manas; García-Ortegón, Miguel; Joshi, Chaitanya K; Hosseini-Gerami, Layla; Beatson, Alex; Greenig, Matthew; Shekhar, Mrinal; Patra, Arijit; Weis, Caroline; Mehrjou, Arash; Badré, Adrien; Paisley, Brianna; Lowe, Rhiannon; Singh, Shantanu; Shah, Falgun; Johannesson, Bjarki; Williams, Dominic; Rouquie, David; Clevert, Djork-Arné; Schwab, Patrick; Richmond, Nicola; Nicolaou, Christos A; Gonzalez, Raymond J; Naven, Russell; Schramm, Carolin; Vidler, Lewis R; Mansouri, Kamel; Walters, W Patrick; Wilk, Deidre Dalmas; Spjuth, Ola; Carpenter, Anne E; Bender, Andreas

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis.

磷酸化诱导嵌合体重塑致癌激酶以触发细胞凋亡

Merz Manuel L, Shoba Veronika M, Pergu Rajaiah, Severance Zachary C, Munkanatta Godage Dhanushka N P, Deb Arghya, Kwok Hui Si, Singh Prashant, Singh Sameek, Allen Jonathan B, Tian Wenzhi, Gosavi Pallavi M, Chaudhary Santosh K, Anokhina Viktoriya, Weisberg Ellen L, Payne N Connor, He Yao, Osadchey Reilly, Shekhar Mrinal, Mazitschek Ralph, Rees Matthew G, Roth Jennifer A, Cui Qiang, Griffin James D, Liau Brian B, Choudhary Amit

Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.

病毒DNA聚合酶结构揭示了抗病毒药物耐药机制

Shankar Sundaresh, Pan Junhua, Yang Pan, Bian Yuemin, Oroszlán Gábor, Yu Zishuo, Mukherjee Purba, Filman David J, Hogle James M, Shekhar Mrinal, Coen Donald M, Abraham Jonathan

Velcrin-induced selective cleavage of tRNA(Leu)(TAA) by SLFN12 causes cancer cell death.

Velcrin诱导的SLFN12对tRNA(Leu)(TAA)的选择性切割导致癌细胞死亡。

Lee Sooncheol, Hoyt Stephanie, Wu Xiaoyun, Garvie Colin, McGaunn Joseph, Shekhar Mrinal, Tötzl Marcus, Rees Matthew G, Cherniack Andrew D, Meyerson Matthew, Greulich Heidi

Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases

蛋白质柔性和解离途径分化可以解释激酶中耐药突变的发生

Shekhar, Mrinal; Smith, Zachary; Seeliger, Markus A; Tiwary, Pratyush

Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations

利用X射线晶体学和分子模拟揭示旋转催化过程中隐藏的中间体

Shekhar, Mrinal; Gupta, Chitrak; Suzuki, Kano; Chan, Chun Kit; Murata, Takeshi; Singharoy, Abhishek

An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections

迭代方法指导FabI抑制剂法比霉素的发现,法比霉素是一种后期抗生素候选药物,对耐药革兰氏阴性菌感染具有体内疗效。

Parker, Erica N; Cain, Brett N; Hajian, Behnoush; Ulrich, Rebecca J; Geddes, Emily J; Barkho, Sulyman; Lee, Hyang Yeon; Williams, John D; Raynor, Malik; Caridha, Diana; Zaino, Angela; Shekhar, Mrinal; Muñoz, Kristen A; Rzasa, Kara M; Temple, Emily R; Hunt, Diana; Jin, Xiannu; Vuong, Chau; Pannone, Kristina; Kelly, Aya M; Mulligan, Michael P; Lee, Katie K; Lau, Gee W; Hung, Deborah T; Hergenrother, Paul J