Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease
在亨廷顿病B6.HttQ111/+小鼠模型中,外周亨廷顿蛋白沉默并不能改善中枢疾病症状。
期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0175968
Coffey, Sydney R; Bragg, Robert M; Minnig, Shawn; Ament, Seth A; Cantle, Jeffrey P; Glickenhaus, Anne; Shelnut, Daniel; Carrillo, José M; Shuttleworth, Dominic D; Rodier, Julie-Anne; Noguchi, Kimihiro; Bennett, C Frank; Price, Nathan D; Kordasiewicz, Holly B; Carroll, Jeffrey B