日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning

非整倍体的蛋白质缓冲作用是由机器学习识别出的协同因素驱动的。

Heller, Erik Marcel; Barthel, Karen; Räschle, Markus; Schukken, Klaske M; Sheltzer, Jason M; Storchová, Zuzana

Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation

通过染色体工程纠正8号染色体上的复杂重排,揭示了8p综合征对基因表达和神经分化的影响

Lee, Sophia N; Banda, Erin C; Qiao, Lu; Thompson, Sarah L; Singh, Karan; Hagenson, Ryan A; Davoli, Teresa; Pinter, Stefan F; Sheltzer, Jason M

A clinical-stage oncology compound selectively targets drug-resistant cancers

一种处于临床阶段的肿瘤化合物可选择性地靶向耐药性癌症。

Long, Kaitlin; Bhattacharjee, Debanjan; Newman-Stonebraker, Samuel H; Suhr, Simon; Mercado, Brandon Q; Scheib, Emily; Tighe, Anthony; Romero, Luciano; Thompson, Sarah L; Sausville, Erin L; John, Kristen M; Julian, Linda; Mishra, Sanat; Klingbeil, Olaf; Gupta, Punya; Bhatt, Uditi; Gao, Allen C; Ricardo, Sara; Vakoc, Christopher R; Bornhauser, Beat C; Corsello, Steven M; Taylor, Stephen S; Chen, Jue; Holland, Patrick L; Sheltzer, Jason M

Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation

通过染色体工程纠正8号染色体上的复杂重排,揭示了8p综合征对基因表达和神经分化的影响

Lee, Sophia N; Banda, Erin C; Qiao, Lu; Thompson, Sarah L; Singh, Karan; Hagenson, Ryan A; Davoli, Teresa; Pinter, Stefan F; Sheltzer, Jason M

Explainable Machine Learning Identifies Factors for Dosage Compensation in Aneuploid Human Cancer Cells

可解释机器学习识别非整倍体人类癌细胞剂量补偿的因素

Heller, Erik Marcel; Barthel, Karen; Räschle, Markus; Schukken, Klaske M; Sheltzer, Jason M; Storchová, Zuzana

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

靶向毒性限制了 CDK11 抑制剂对 1p36 缺失癌症的疗效

Julian Linda, Crozier Lisa, Lukow Devon, Mishra Sanat, Swamy Aditi, Hagenson Ryan A, Sennhenn Peter, Sausville Erin L, Mendelson Brianna, Chuaqui Claudio, Qiao Lu, Vasudevan Anand, Lin Kuan-Ting, Bhatia Sonam, Bertomeu Thierry, Chatr-Aryamontri Andrew, Zhang Li, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Nottoli Timothy, Bai Suxia, Lakshmipathi Jayalakshmi, Muthusamy Viswanathan, Van Vranken Jonathan G, Gygi Steven P, Thompson Sarah L, Smith Joan C, Anderson Kendall, Shah Sanjana, Bindra Ranjit S, Akerman Martin, Spector David L, Krainer Adrian R, Sheltzer Jason M

Evolving copy number gains promote tumor expansion and bolster mutational diversification

拷贝数增加会促进肿瘤扩张并增强突变多样性

Wang, Zicheng; Xia, Yunong; Mills, Lauren; Nikolakopoulos, Athanasios N; Maeser, Nicole; Dehm, Scott M; Sheltzer, Jason M; Sun, Ruping

An elevated rate of whole-genome duplications in cancers from Black patients

黑人患者癌症的全基因组重复率较高

Leanne M Brown #, Ryan A Hagenson #, Tilen Koklič, Iztok Urbančič, Lu Qiao, Janez Strancar, Jason M Sheltzer

Aneuploidy in human cancer: new tools and perspectives

人类癌症中的非整倍体:新的工具和视角

Lakhani, Asad A; Thompson, Sarah L; Sheltzer, Jason M

Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor

抑制较低效力靶点可推动临床 p38 抑制剂的抗癌活性

Debanjan Bhattacharjee, Jaweria Bakar, Surbhi P Chitnis, Erin L Sausville, Kumar Dilip Ashtekar, Brianna E Mendelson, Kaitlin Long, Joan C Smith, David E Heppner, Jason M Sheltzer