日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

In situ visualization of Clostridioides difficile phenotypic heterogeneity and single-cell morphology during gut infection

肠道感染过程中艰难梭菌表型异质性和单细胞形态的原位可视化

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-68411-6
DiBenedetto, Nicholas V; Donnelly-Morell, M Lauren; Kumamoto, Carol A; Shen, Aimee
炎症/感染
细胞生物学
单细胞
发表日期：2026
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The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination

CspC:CspA 异二聚体在艰难梭菌孢子萌发过程中转导萌发和共萌发信号

期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.3003610
McNellis, Morgan E; González-Del Pino, Gonzalo; Serrano-Jiménez, Juan A; Forster, Emily R; Stoica, Anca Ioana; Heldwein, Ekaterina E; Shen, Aimee
信号转导
发表日期：2026
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Defining the order of assembly of the Clostridioides difficile divisome complex

确定艰难梭菌分裂体复合物的组装顺序

期刊:
影响因子:
doi:10.64898/2026.01.19.700290
Harrison, Gregory A; Kuhn, Pola; Shrestha, Shailab; Blanco, Paula Caballero; Havey, Larissa; Shen, Aimee
发表日期：2026
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Protection against Clostridioides difficile disease by a naturally avirulent strain.

利用天然无毒菌株预防艰难梭菌病

期刊:Cell Host & Microbe
影响因子:18.7
doi:10.1016/j.chom.2024.11.003
Dong Qiwen, Harper Stephen, McSpadden Emma, Son Sophie S, Allen Marie-Maude, Lin Huaiying, Smith Rita C, Metcalfe Carolyn, Burgo Victoria, Woodson Che, Sundararajan Anitha, Rose Amber, McMillin Mary, Moran David, Little Jessica, Mullowney Michael W, Sidebottom Ashley M, Fortier Louis-Charles, Shen Aimee, Pamer Eric G
其它
肠道菌群
发表日期：2025
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Flagellar switch inverted repeats impact heterogeneity in flagellar gene expression and thus C. difficile RT027/MLST1 virulence.

鞭毛转换反向重复序列影响鞭毛基因表达的异质性，从而影响艰难梭菌 RT027/MLST1 的毒力

期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2025.115830
Nhu Nguyen T Q, Lin Huaiying, Pigli Ying, Sia Jonathan K, Kuhn Pola, Ruppel Hannah, Snitkin Evan S, Young Vincent B, Kamboj Mini, Pamer Eric G, Rice Phoebe A, Shen Aimee, Dong Qiwen
其它
肠道菌群
发表日期：2025
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Penicillin-binding proteins exhibit functional redundancy during asymmetric cell division in Clostridioides difficile

艰难梭菌不对称细胞分裂过程中，青霉素结合蛋白表现出功能冗余性。

期刊:Journal of Bacteriology
影响因子:3
doi:10.1128/jb.00503-25
Shrestha, Shailab; Harrison, Gregory A; Dressler, Jules M; McNellis, Morgan E; Shen, Aimee
细胞生物学
发表日期：2025
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Functional redundancy between penicillin-binding proteins during asymmetric cell division in Clostridioides difficile

艰难梭菌不对称细胞分裂过程中青霉素结合蛋白的功能冗余

期刊:
影响因子:
doi:10.1101/2024.09.26.615255
Shrestha, Shailab; Dressler, Jules M; Harrison, Gregory A; McNellis, Morgan E; Shen, Aimee
细胞生物学
发表日期：2025
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Diversification of division mechanisms in endospore-forming bacteria revealed by analyses of peptidoglycan synthesis in Clostridioides difficile

通过对艰难梭菌肽聚糖合成的分析揭示了内生孢子形成细菌分裂机制的多样化

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-023-43595-3
Shrestha, Shailab; Taib, Najwa; Gribaldo, Simonetta; Shen, Aimee
微生物学
发表日期：2023
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Single-spore germination analyses reveal that calcium released during Clostridioides difficile germination functions in a feedforward loop

单孢子萌发分析表明，艰难梭菌萌发过程中释放的钙在正反馈回路中发挥作用。

期刊:mSphere
影响因子:3.1
doi:10.1128/msphere.00005-23
Ribis, John W; Melo, Luana; Shrestha, Shailab; Giacalone, David; Rodriguez, Enrique E; Shen, Aimee; Rohlfing, Amy
发表日期：2023
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Analyses of cell wall synthesis in Clostridioides difficile reveal a diversification in cell division mechanisms in endospore-forming bacteria

对艰难梭菌细胞壁合成的分析揭示了内生孢子形成细菌细胞分裂机制的多样化

期刊:
影响因子:
doi:10.1101/2023.08.06.552200
Shrestha, Shailab; Taib, Najwa; Gribaldo, Simonetta; Shen, Aimee
微生物学
细胞生物学
发表日期：2023
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