日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

New selective and allosteric FLT3 inhibitors show efficacy against resistant acute myeloid leukemia cells.

新型选择性变构FLT3抑制剂对耐药性急性髓系白血病细胞显示出疗效。

Ge Shuai-Shuai, Qiu Qiao-Cheng, Hua Jingsheng, Wang Jun, Yang Minfeng, Du Jiahui, Huang Yuan-Hong, Wan Chao-Ling, Liu Ling-Ling, Dai Hai-Ping, Zhang Maofeng, Shen Binghui, Xue Sheng-Li, Chen Fang, Liu Song-Bai

DNA2 and MSH2 cooperatively repair stabilized G4 and allow efficient telomere replication.

DNA2 和 MSH2 协同修复稳定的 G4,并实现有效的端粒复制。

Fernandez Anthony, Zhou Tingting, Lei Yi, Liu Nian, Esworthy Steven, Shen Changxian, Liu Helen, Hess Jessica D, Yuan Hang, Shi Guojun, Zhou Mian, Shen Lei, Zhang Sufang, Kosiyatrakul Settapong, Gaur Vikas, Sommers Joshua A, Srivastava Nityanand, Edelmann Winfried, Li Guo-Min, Brosh Robert M Jr, Chai Weihang, Lee Marietta Y W T, Zhang Dong, Schildkraut Carl, Zheng Li, Shen Binghui

KRAS-induced STN1 (OBFC1) promotes proper CTC1-STN1-TEN1 complex-independent DNA double-strand break repair and cell cycle checkpoint maintenance in pancreatic cancer

KRAS诱导的STN1(OBFC1)促进胰腺癌中不依赖于CTC1-STN1-TEN1复合物的DNA双链断裂修复和细胞周期检查点维持。

Shen, Changxian; Cui, Tiantian; Yang, Linlin; Gui, Ling; Corrales-Guerrero, Sergio; Nair, Sindhu; Li, Haiqing; Karasinska, Joanna M; Topham, James T; Renouf, Daniel J; Schaeffer, David F; Fernandez, Anthony; Ping, Xiaoli; Shen, Binghui; Stark, Jeremy M; Williams, Terence M

Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer Therapy

发现和表征靶向核酸外切酶1的小分子抑制剂,用于同源重组缺陷型癌症治疗

Wang, Yixing; Hess, Jessica D; Wang, Chen; Ma, Lingzi; Luo, Megan; Jossart, Jennifer; Perry, John J; Kwon, David; Wang, Zhe; Pei, Xinyu; Shen, Changxian; Wang, Yingying; Zhou, Mian; Yin, Holly; Horne, David; Nussenzweig, André; Zheng, Li; Shen, Binghui

DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres

DNA2 和 FANCM 通过两条不同的途径破坏 TERRA R 环并抑制 ALT 端粒的复制压力。

Ragupathi, Ashwin; Abid, Heba Z; Chen, Yun; Zhao, Rongwei; Kosiyatrakul, Settapong T; Yetil, Derin I; Neiswander, Julia; Feltman, Rachel; Thomas, Shannon; Yusupov, Benjamin; Singh, Manrose; Zheng, Li; Shen, Binghui; Zhang, Huaiying; Chu, Hsueh-Ping C; Schildkraut, Carl L; Xiao, Ming; Zhang, Dong

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation

XPF介导3'瓣加工,实现FEN1非依赖性的冈崎片段成熟

Li, Kejiao; Yang, Feng; Wang, Yingying; Shi, Guojun; Yan, Yao; Lei, Yi; Wang, Yixing; Zhou, Main; Sun, Haitao; Zheng, Li; Shen, Binghui

JMJD1B-mediated FEN1 demethylation allows timely switching of Okazaki fragment maturation core enzymes to avoid mutagenic flap ligation by PARP1-LIG3

JMJD1B介导的FEN1去甲基化可使冈崎片段成熟核心酶及时切换,从而避免PARP1-LIG3介导的诱变性瓣状结构连接。

Yan, Yao; Shi, Guojun; Li, Kejiao; Lei, Yi; Wang, Yixing; Wang, Yingying; Liu, Songbai; Fernandez, Anthony; Zhou, Tingting; Wang, Evan; Zhou, Mian; Hang, Yuan; Li, Zhuo; Guo, Zhigang; Zheng, Li; Shen, Binghui

Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells

癌代谢产物富马酸通过琥珀酰化RPA1来损害富马酸水合酶缺陷型肾细胞癌细胞中的ATR-CHK1信号通路。

Liu, Nian; Shen, Changxian; Zhou, Tingting; Zhou, Yu; Yuan, Hang; Bi, Hongjie; Wang, Yingying; Pei, Xinyu; Su, Rui; Zheng, Li; Shi, Yihui; Shen, Binghui

Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury

巨核细胞 IGF1 协调激活和铁死亡以保障放射损伤后的造血干细胞再生

Weinian Liao #, Xinliang Chen #, Shuzhen Zhang, Jun Chen, Chaonan Liu, Kuan Yu, Yimin Zhang, Mo Chen, Fang Chen, Mingqiang Shen, Binghui Lu, Songling Han, Song Wang, Junping Wang, Changhong Du

KDM3B Single-Nucleotide Polymorphisms Impact Radiation Therapy Toxicity Through Circular RNA-Mediated KDM3B Expression and Inflammatory Responses

KDM3B单核苷酸多态性通过环状RNA介导的KDM3B表达和炎症反应影响放射治疗毒性

Sun, Yin; Tsai, Ying; Wood, Ronald; Shen, Binghui; Chen, Jinbo; Zhou, Zhen; Zeng, Guohua; Marples, Brian; Kerns, Sarah; Chen, Yuhchyau