日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Physiologically based Pharmacokinetic Model Validated to Enable Predictions Of Multiple Drugs in a Long-acting Drug-combination Nano-Particles (DcNP): Confirmation with 3 HIV Drugs, Lopinavir, Ritonavir, and Tenofovir in DcNP Products

基于生理的药代动力学模型经验证可用于预测长效药物组合纳米颗粒 (DcNP) 中多种药物的药代动力学:以三种 HIV 药物(洛匹那韦、利托那韦和替诺福韦)在 DcNP 产品中的药代动力学为验证

Perazzolo, Simone; Shen, Danny D; Scott, Ariel M; Ho, Rodney J Y

Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease.

将尿毒症溶质介导的 OAT1/3 抑制纳入 PBPK 预测,可改善重度肾病患者替诺福韦肾脏和全身分布情况

Chang Shih-Yu, Huang Weize, Chapron Alenka, Quiñones Antonio J López, Wang Joanne, Isoherranen Nina, Shen Danny D, Kelly Edward J, Himmelfarb Jonathan, Yeung Catherine K

Co-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants

在健康成年受试者中,同时饮用绿茶和服用雷洛昔芬会降低雷洛昔芬的全身暴露量。

Clarke, John D; Judson, Sabrina M; Tian, Dan-Dan; Kirby, Trevor O; Tanna, Rakshit S; Matula-Péntek, Adrienn; Horváth, Miklós; Layton, Matthew E; White, John R; Cech, Nadja B; Thummel, Kenneth E; McCune, Jeannine S; Shen, Danny D; Paine, Mary F

Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-Drug Mixture

基于生理的HIV药物联合用药药代动力学模型及其皮下给药后淋巴系统的作用。第一部分:游离药物混合物模型

Perazzolo, Simone; Shireman, Laura M; Shen, Danny D; Ho, Rodney J Y

Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial

圣约翰草对静脉注射芬太尼药代动力学、药效学和临床疗效的影响:一项随机临床试验

Loughren, Michael J; Kharasch, Evan D; Kelton-Rehkopf, Megan C; Syrjala, Karen L; Shen, Danny D

Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus

格列本脲、二甲双胍及格列本脲/二甲双胍联合疗法治疗妊娠期糖尿病的药效学

Shuster, Diana L; Shireman, Laura M; Ma, Xiaosu; Shen, Danny D; Flood Nichols, Shannon K; Ahmed, Mahmoud S; Clark, Shannon; Caritis, Steve; Venkataramanan, Raman; Haas, David M; Quinney, Sara K; Haneline, Laura S; Tita, Alan T; Manuck, Tracy A; Thummel, Kenneth E; Brown, Linda Morris; Ren, Zhaoxia; Brown, Zane; Easterling, Thomas R; Hebert, Mary F

Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101

结合计算和实验方法阐明注射用三联抗HIV药物组合TLC-ART 101的首过淋巴药物滞留机制和长效药代动力学

Perazzolo, Simone; Shireman, Laura M; McConnachie, Lisa A; Koehn, Josefin; Kinman, Loren; Lee, Wonsok; Lane, Sarah; Collier, Ann C; Shen, Danny D; Ho, Rodney J Y

Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus

二甲双胍在妊娠期糖尿病孕妇和非妊娠期2型糖尿病女性中的药效学

Shuster, Diana L; Shireman, Laura M; Ma, Xiaosu; Shen, Danny D; Flood Nichols, Shannon K; Ahmed, Mahmoud S; Clark, Shannon; Caritis, Steve; Venkataramanan, Raman; Haas, David M; Quinney, Sara K; Haneline, Laura S; Tita, Alan T; Manuck, Tracy A; Thummel, Kenneth E; Morris Brown, Linda; Ren, Zhaoxia; Brown, Zane; Easterling, Thomas R; Hebert, Mary F

Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation

基于机制的药代动力学 (MBPK) 模型描述了由长效抗 HIV 药物组合纳米颗粒制剂递送的三种抗逆转录病毒药物的复杂血浆动力学。

Kraft, John C; McConnachie, Lisa A; Koehn, Josefin; Kinman, Loren; Sun, Jianguo; Collier, Ann C; Collins, Carol; Shen, Danny D; Ho, Rodney J Y

Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of Para-Hydroxymethamphetamine

甲基苯丙胺及其主要代谢物在小鼠体内的分布:有机阳离子转运蛋白3在对羟基甲基苯丙胺组织选择性蓄积中的作用

Wagner, David J; Shireman, Laura M; Ahn, Sojung; Shen, Danny D; Wang, Joanne