EZH2 suppresses IR-induced ferroptosis by forming a co-repressor complex with HIF-1α to inhibit ACSL4: Targeting EZH2 enhances radiosensitivity in KDM6A-deficient esophageal squamous carcinoma
EZH2通过与HIF-1α形成共抑制复合物来抑制ACSL4,从而抑制IR诱导的铁死亡:靶向EZH2可增强KDM6A缺陷型食管鳞状细胞癌的放射敏感性
期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-025-01451-5
Pan, Guizhen; Xia, Yeye; Hao, Mengyu; Guan, Jiahao; Zhu, Qianqian; Zha, Tianqi; Sheng, Lei; Zhao, Zhenfeng; Pan, Huaguang; Fang, Weiyang; Xu, Xiaoyong; Chen, Xiangcun; Zhou, Shuguang; Tong, Zhuting
肿瘤
肿瘤免疫
ACSL4
铁死亡
KDM6A
EZH2
细胞生物学