Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2
3-(咪唑并[1,2- a]吡嗪-3-基乙炔基)-4-异丙基-N-(3-((4-甲基哌嗪-1-基)甲基)-5-(三氟甲基)苯基)苯甲酰胺作为盘状结构域受体 1 和 2 的双重抑制剂的设计、合成及生物学评价
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.8b01045
Zhen Wang, Yali Zhang, Daniel M Pinkas, Alice E Fox, Jinfeng Luo, Huocong Huang, Shengyang Cui, Qiuping Xiang, Tingting Xu, Qiuju Xun, Dongsheng Zhu, Zhengchao Tu, Xiaomei Ren, Rolf A Brekken, Alex N Bullock, Guang Liang, Ke Ding, Xiaoyun Lu
