日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis

发现一种ITK和TRK激酶抑制剂,可用于治疗特应性皮炎。

Duffen, Jennifer L; Crouse, Kimberly K; Ji, Lin; Brault, Amy L; Ford, Kristen; Brooks, Jonathan; Jelinsky, Scott A; Li, Yizheng; Shin, Julia H; Zhao, Yajuan; Andreyeva, Tatyana; Hammerman, Katherine; Arnold, Christina; Sheldon, Richard T; Garren, Jeonifer; LaBarge, Wes; Resek, Anthony; Volmer, Jon; Bagley, Scott W; Casimiro-Garcia, Agustin; Chinigo, Gary M; Davoren, Jennifer E; Denny, Rajiah Aldrin; Drozda, Susan; Foley, Timothy L; Hicklin, Robert W; Liu, Shenping; Lovering, Frank E; Nedoma, Nicole L; Parikh, Mihir D; Strohbach, Joseph W; Trujillo, John I; Steyn, Stefanus J; Nocka, Karl; Hegen, Martin; Vincent, Fabien; Lee, Katherine L; Gerstenberger, Brian S; Primiano, Michael J

Nanozymes Integrated Biochips Toward Smart Detection System

纳米酶集成生物芯片在智能检测系统中的应用

Chen, Dongyu; Zheng, Wang; Zhang, Zhihui; Yu, Shenping; Hang, Xinxin; Wu, Han; Xiang, Xiao-Wei; Mu, Wei; Jiao, Yanli; Dong, Zaizai; Chang, Lingqian

Visualizing the translation landscape in human cells at high resolution

高分辨率可视化人类细胞中的翻译图谱

Zheng, Wei; Zhang, Yuekang; Wang, Jimin; Wang, Shuhui; Chai, Pengxin; Bailey, Elizabeth J; Zhu, Chenghao; Guo, Wangbiao; Devarkar, Swapnil C; Wu, Shenping; Lin, Jianfeng; Zhang, Kai; Liu, Jun; Lomakin, Ivan B; Xiong, Yong

Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants

合成17B-HSD13底物的设计和应用揭示了保护性人类变体的催化活性得以保留

Garnsey, Michelle R; Wang, Yang; Edmonds, David J; Sammons, Matthew F; Reidich, Benjamin; Ahn, Youngwook; Ashkenazi, Yotam; Carlo, Anthony; Cerny, Matthew A; Coffman, Karen J; Culver, Jeffrey A; Dechert Schmitt, Anne-Marie; Eng, Heather; Fisher, Ethan L; Gutierrez, Jemy A; James, Larry; Jordan, Samantha; Kohrt, Jeffrey T; Kramer, Melissa; LaChapelle, Erik A; Lee, Jack C; Lee, Jisun; Li, Dongmei; Li, Zhenhong; Liu, Shenping; Liu, Jianhua; Magee, Thomas V; Miller, Melissa R; Moran, Michael; Nason, Deane M; Nedoma, Nicole L; O'Neil, Steven V; Piotrowski, Mary A; Racich, Jillian; Sommese, Ruth F; Stevens, Lucy M; Wright, Ann S; Xiao, Jun; Zhang, Liying; Zhou, Dahui; Barrandon, Ornella; Clasquin, Michelle F

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca(2+) dependent allosteric binding site.

通过靶向 Ca(2+) 依赖性变构结合位点来抑制肽基精氨酸脱亚胺酶 (PAD1-4)

Dakin Leslie A, Xing Li, Hall Justin, Ding Weidong, Vajdos Felix F, Pelker Jeffrey W, Ramsey Simeon, Balbo Paul, Sahasrabudhe Parag V, Banker Mary Ellen, Choi Won Young, Wright Stephen W, Chang Jeanne S, Curto John M, Davoren Jennifer E, Drozda Susan E, Fennell Kimberly F, Futatsugi Kentaro, Kortum Steve, Lee Katherine L, Liu Shenping, Lovering Frank, Nicki Jennifer A, Trujillo John I, Vincent Fabien, Schnute Mark E

In situ structures of the Legionella Dot/Icm T4SS identify the DotA-IcmX complex as the gatekeeper for effector translocation

军团菌 Dot/Icm T4SS 的原位结构表明,DotA-IcmX 复合物是效应蛋白转运的“守门人”。

Yue, Jian; Heydari, Samira; Park, Donghyun; Chetrit, David; Tachiyama, Shoichi; Guo, Wangbiao; Botting, Jack M; Wu, Shenping; Roy, Craig R; Liu, Jun

Multi-omics analysis guided discovery: hydroxyproline enhance muscle hardness of hybrid bream (BBTB, Megalobrama amblycephala ♀ × Culter alburnus ♂) via myofiber proliferation and collagen deposition

多组学分析指导发现:羟脯氨酸通过肌纤维增殖和胶原沉积增强杂交鲷鱼(BBTB,Megalobrama amblycephala ♀ × Culter alburnus ♂)的肌肉硬度。

Anli Zuo ,Zhehua Xu ,Yimiao He ,Junchi Zhao ,Qianting Zheng ,Mingyu Zhang ,Weiting Zhang ,Jianzhou Tang ,Shenping Cao ,Qiong Zhao ,Junyan Jin ,Zhen Liu

Bacteriophage P1 protein Icd inhibits bacterial division by targeting FtsZ

噬菌体P1蛋白Icd通过靶向FtsZ抑制细菌分裂。

Zhao, Kairui; Du, Shuheng; Tian, Linlin; Wang, Shenping; Shi, Runqin; Sun, Haiyu; Zhou, Yao; Huang, Chenhao; Sun, Yanmei; Wang, Shiwei; Chen, Yaodong

The Joint Contribution of Host Genetics and Probiotics to Pig Growth Performance

宿主遗传和益生菌对猪生长性能的共同贡献

Han, Jinyi; Wang, Mingyu; Zhou, Shenping; Wang, Zhenyu; Duan, Dongdong; Li, Mengyu; Li, Xiuling; Xin, Wenshui; Li, Xinjian

A meta-analysis of genome-wide association studies revealed significant QTL and candidate genes for loin muscle area in three breeding pigs

对全基因组关联研究的荟萃分析揭示了三种种猪腰肌面积的显著数量性状位点(QTL)和候选基因。

Zhenyu, Wang; Mengyu, Li; Dongdong, Duan; Jinyi, Han; Chuanmin, Qiao; Hao, Zhou; Xinjian, Li; Shenping, Zhou; Wenshui, Xin