Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
脑啡肽酶的过表达可减少阿尔茨海默病淀粉样蛋白β42 (Aβ42) 诱导的神经元丢失和神经元内Aβ42沉积，但会导致cAMP反应元件结合蛋白介导的转录减少、年龄依赖性轴突病变以及果蝇过早死亡。
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M710509200
Iijima-Ando, Kanae; Hearn, Stephen A; Granger, Linda; Shenton, Christopher; Gatt, Anthony; Chiang, Hsueh-Cheng; Hakker, Inessa; Zhong, Yi; Iijima, Koichi
Drosophila
阿尔茨海默症
GPCR/Calcium/cAMP
神经科学
