A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
通过同时设计亲和力、选择性、稳定性和 FcRn 结合,实现具有优异体内疗效的 CD80 偏向性 CTLA4-Ig 融合蛋白
期刊:Journal of Immunology
影响因子:3.6
doi:10.4049/jimmunol.1600682
Julie Douthwaite, Jacques Moisan, Cyril Privezentzev, Blagoje Soskic, Shereen Sabbah, Suzanne Cohen, Andie Collinson, Elizabeth England, Catherine Huntington, Ben Kemp, Li Zhuang, Suzanne Hudak, D Gareth Rees, Debbie Goldberg, Chris Barton, Linda Chang, Inna Vainshtein, Meina Liang, Laurie Iciek, Ph