日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA

通过P450氧化还原伴侣优化和DoxA结构分析对阿霉素生物合成进行代谢工程改造

Koroleva, Arina; Artukka, Erika; Yamada, Keith; Newmister, Sean A; Harte, Ralph J; Boesger, Hannah; Londen, Mikael; Sanders, Jacob N; Tirkkonen, Heli; Kannisto, Matti; Kuin, Rosan C M; Hulst, Mandy; Wang, Rongbin; Leskinen, Ester; Barillec, Morgane; Niemi, Jarmo; van Wezel, Gilles P; Neefjes, Jacques; Nybo, S Eric; Houk, Kendall N; Sherman, David H; Kim, Robbert Q; Metsä-Ketelä, Mikko

Structural Diversification of 14-Membered Macrolides by Chemoenzymatic Synthesis

通过化学酶法合成实现14元大环内酯的结构多样化

Curtis, Brian J; Boesger, Hannah A; Schmidt, Jennifer J; Adrover-Castellano, Maria L; Momin, Areeba N; Glasser, Carolyn A; Sherman, David H

Investigating Opioid Receptor Activity through Biocatalytic Halogenation and Oxidation of Mitragynine

通过生物催化卤化和氧化帽柱木碱研究阿片受体活性

Harris, Natalia R; Powell, Alexander J; Snodgrass, Harrison M; Amin, Sahar; Newmister, Sean A; Curtis, Brian J; Li, Danny; Husaini, Zehra A; Verhey-Henke, Linnea; Smith, Janet L; Pereira, Filipa; Lewis, Jared C; Traynor, John; Sherman, David H

The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids

真菌双环[2.2.2]二氮杂辛烷吲哚生物碱的相互启发式生物和化学合成

Du, Lei; Dian, Longyang; Newmister, Sean A; Xia, Yuwei; Luo, Guanzhong; Sherman, David H; Li, Shengying

Establishing Selectivity Trends with Reactions of Thioesterases and Semi-Synthetic Polyketides

利用硫酯酶和半合成聚酮化合物的反应建立选择性趋势

Litman, Zachary C; Chen, Yuanhuang; Sherman, David H

Engineering a Biosynthetic Pathway to Produce (+)-Brevianamides A and B

构建生物合成途径以生产 (+)-布雷维酰胺 A 和 B

Sandoval Hurtado, Casandra P; Kelly, Samantha P; Shende, Vikram; Perez, Makayla; Curtis, Brian J; Newmister, Sean A; Ott, Kaleb; Pereira, Filipa; Sherman, David H

Directed Evolution of a Modular Polyketide Synthase Thioesterase for Generation of a Hybrid Macrocyclic Ring System

利用模块化聚酮合酶硫酯酶定向进化生成杂化大环体系

Adrover-Castellano, Maria L; Curtis, Brian J; Schmidt, Jennifer J; Boesger, Hannah A; Glasser, Carolyn A; Olukorede, Damilola E; Qu, Fengrui; Sherman, David H

Optimized production of concanamycins using a rational metabolic engineering strategy.

利用合理的代谢工程策略优化康卡那霉素的生产

Pereira Filipa, McCauley Morgan, Lev Katherine, Verhey-Henke Linnea, Condren Alanna R, Harte Ralph J, Galvez Jesus, Sherman David H

Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A

代谢工程和后期功能化扩展了抗疟药普瑞马利尼奥辛A的化学空间。

McBride, Christina M; McCauley, Morgan; Harris, Natalia R; Amin, Sahar; Curtis, Brian J; Verhey-Henke, Linnea; Teklemichael, Awet A; Oliphant, Erin N; Dranchak, Patricia; Lev, Katherine L; Qu, Fengrui; Snodgrass, Harrison M; Lewis, Jared C; Inglese, James; Su, Xin-Zhuan; Pereira, Filipa; Sherman, David H

Structure of a putative terminal amidation domain in natural product biosynthesis

天然产物生物合成中假定的末端酰胺化结构域的结构

Rankin, Michael R; Khare, Dheeraj; Gerwick, Lena; Sherman, David H; Gerwick, William H; Smith, Janet L