日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EZH2 PROTACs outperform catalytic inhibitors in prostate cancer by targeting a methylation-independent function of PRC2

EZH2 PROTACs 通过靶向 PRC2 的甲基化非依赖性功能,在治疗前列腺癌方面优于催化抑制剂。

Wanqing Xie,Qi Chu,Lourdes Brea,Guihua Zeng,Yuan Wang,Xiaodong Lu,Mohan Zheng,Corinne R Ley,Zhiquan Lei,Hongshun Shi,Joshua L Zhu,Lihu Gong,M Cynthia Martin,Xianglin Shi,Galina Gritsina,Arabela A Grigorescu,Hana Chandonnet,Xin Liu,Jonathan C Zhao,Gary E Schiltz,Jindan Yu

Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy.

遗传性出血性毛细血管扩张症基因治疗中AAV衣壳和递送方法的评估

Yadav Alka, Liang Rich, Press Kelly, Schmidt Annika, Shabani Zahra, Leng Kun, Wang Calvin, Sekhar Abinav, Shi Joshua, Devlin Garth W, Gonzalez Trevor J, Asokan Aravind, Su Hua

Mutation of platelet-derived growth factor receptor β causes and exacerbates the severity of brain arteriovenous malformation through enhancing angiogenesis

血小板衍生生长因子受体β的突变通过增强血管生成,导致并加剧脑动静脉畸形的严重程度。

Yadav, Alka; Prado, Leandro Barbosa Do; Mohamed, Mustafa; Wang, Calvin; Shi, Joshua; Shabani, Zahra; Liang, Rich; Press, Kelly; Tom, Courtney; Winkler, Ethan A; Su, Hua

Increased Synapse Elimination by Inflammatory Cells Contributes to Long-lasting Post-Stroke Memory Dysfunction in Old Mice.

炎症细胞对突触的破坏增加,导致老年小鼠中风后长期记忆功能障碍

Shabani Zahra, Pan Peipei, Li Qifeng, Wang Zhanqiang, Leng Kun, Sangras Shalika, Huo Kang, Yadav Alka, Wang Calvin, Shi Joshua, Chinn Gregory, Kyritsis Nikolas, Ferguson Adam R, Hellman Judith, Su Hua

Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer

综合分析突显了转移性前列腺癌中三维基因组与DNA、RNA和表观基因组改变之间的相互作用

Shuang G Zhao #,Matthew Bootsma #,Stanley Zhou #,Raunak Shrestha,Thaidy Moreno-Rodriguez,Arian Lundberg,Chu Pan,Christopher Arlidge,James R Hawley,Adam Foye,Alana S Weinstein,Martin Sjöström,Meng Zhang,Haolong Li,Lisa N Chesner,Nicholas R Rydzewski,Kyle T Helzer,Yue Shi,Joshua M Lang,Joshi J Alumkal,Hansen H He,Alexander W Wyatt,Rahul Aggarwal,Wilbert Zwart,Eric J Small,David A Quigley,Mathieu Lupien,Felix Y Feng

A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

用于评估癌症检测组合检测低等位基因频率小变异性能的已验证基因组参考样本

Wendell Jones ,Binsheng Gong ,Natalia Novoradovskaya ,Dan Li ,Rebecca Kusko ,Todd A Richmond ,Donald J Johann Jr ,Halil Bisgin ,Sayed Mohammad Ebrahim Sahraeian ,Pierre R Bushel ,Mehdi Pirooznia ,Katherine Wilkins ,Marco Chierici ,Wenjun Bao ,Lee Scott Basehore ,Anne Bergstrom Lucas ,Daniel Burgess ,Daniel J Butler ,Simon Cawley ,Chia-Jung Chang ,Guangchun Chen ,Tao Chen ,Yun-Ching Chen ,Daniel J Craig ,Angela Del Pozo ,Jonathan Foox ,Margherita Francescatto ,Yutao Fu ,Cesare Furlanello ,Kristina Giorda ,Kira P Grist ,Meijian Guan ,Yingyi Hao ,Scott Happe ,Gunjan Hariani ,Nathan Haseley ,Jeff Jasper ,Giuseppe Jurman ,David Philip Kreil ,Paweł Łabaj ,Kevin Lai ,Jianying Li ,Quan-Zhen Li ,Yulong Li ,Zhiguang Li ,Zhichao Liu ,Mario Solís López ,Kelci Miclaus ,Raymond Miller ,Vinay K Mittal ,Marghoob Mohiyuddin ,Carlos Pabón-Peña ,Barbara L Parsons ,Fujun Qiu ,Andreas Scherer ,Tieliu Shi ,Suzy Stiegelmeyer ,Chen Suo ,Nikola Tom ,Dong Wang ,Zhining Wen ,Leihong Wu ,Wenzhong Xiao ,Chang Xu ,Ying Yu ,Jiyang Zhang ,Yifan Zhang ,Zhihong Zhang ,Yuanting Zheng ,Christopher E Mason ,James C Willey ,Weida Tong ,Leming Shi ,Joshua Xu

Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

抗癌药物亚胺吡啶酮 ONC201 的药理学表征揭示了其对 D2 多巴胺受体的负变构作用机制

R Benjamin Free, Caroline A Cuoco, Bing Xie, Yoon Namkung, Varun V Prabhu, Blair K A Willette, Marilyn M Day, Marta Sanchez-Soto, J Robert Lane, Stéphane A Laporte, Lei Shi, Joshua E Allen, David R Sibley

A hybrid protein-polymer nanoworm potentiates apoptosis better than a monoclonal antibody

混合蛋白质-聚合物纳米蠕虫比单克隆抗体更能促进细胞凋亡

Suhaas Rayudu Aluri, Pu Shi, Joshua A Gustafson, Wan Wang, Yi-An Lin, Honggang Cui, Shuanglong Liu, Peter S Conti, Zibo Li, Peisheng Hu, Alan L Epstein, John Andrew MacKay

Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression

鉴定谷胱甘肽 S-转移酶 pi 为参与帕金森病进展的蛋白质

Min Shi, Joshua Bradner, Theo K Bammler, David L Eaton, Jianpeng Zhang, ZuCheng Ye, Angela M Wilson, Thomas J Montine, Catherine Pan, Jing Zhang