Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models.
PRMT5 和 MAT2A 的联合抑制在 MTAP 纯合缺陷型胶质瘤模型中表现出强烈的合成致死性
期刊:Cell Death Discovery
影响因子:7
doi:10.1038/s41420-025-02545-2
Jiang Zuoyu, Li Xuetao, Xiao Zongyu, Gan Wenjuan, Zhang Xuewen, Zhang Yang, Wang Weichao, E Qinzhi, Huang Yu, Shi Qikun, Tang Yi, Du Jiaming, Dong Hanmiao, Li Jian, Huang Yulun
