日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Efficacy and safety of garsorasib in patients with KRAS G12C-mutated advanced pancreatic cancer

加索拉西布治疗KRAS G12C突变晚期胰腺癌患者的疗效和安全性

Yamamoto, Noboru; Yan, Dong; Ganju, Vinod; Hou, Xinfang; Pan, Hongming; Shan, Jianzhen; Wang, Liwei; Kim, Sang-We; Richardson, Gary; Sanborn, Rachel E; Zhang, Jingdong; Xiang, Ziyong; Wang, Wenjia; Shi, Zhe; Zhang, Ling; Wang, Yaolin; Xu, Rui-Hua

Wuji Pill and Akkermansia muciniphila alleviates intestinal dysfunction and depression-like behavior in irritable bowel syndrome through the microbiota-gut-brain axis

无极丸和阿克曼菌(Akkermansia muciniphila)通过肠道菌群-肠-脑轴缓解肠易激综合征的肠道功能障碍和抑郁样行为。

Li, Mengting; Xiao, Shuiming; Wang, Yanli; Li, Tao; Hu, Qin; Dong, Lijinchuan; Guo, Yuxuan; Shi, Zhe; Yang, Qing; Cai, Weiyan; Li, Qi; Peng, Bo; Li, Pengyue; Weng, Xiaogang; Wang, Yajie; Li, Yujie; Dong, Yu; Zhu, Xiaoxin; Gong, Zipeng; Chen, Ying

Locating the epileptogenic zone for drug-resistant epilepsy through neuroelectrophysiological brain network topology

通过神经电生理脑网络拓扑学定位耐药性癫痫的致痫灶

Zhang, Wenzhao; Shi, Zhe; Kong, Weixin; Gong, Yuanchu; Lin, Wentao; Wu, Zhijun; Han, Yanming; Liu, Yaqing; Wang, Tiancheng

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral TYK2 Inhibitor D-2570 in Healthy Subjects: A First-in-Human Phase I Study

口服 TYK2 抑制剂 D-2570 在健康受试者中的安全性、耐受性、药代动力学和药效学:一项首次人体 I 期研究

Wang, Meng; Zhang, Quanying; Shi, Zhe; Zhang, Ling; Pan, Jie

Lactoferrin combined with Bifidobacterium animalis subsp. lactis BB-12 improves respiratory tract infections and modulates Gut microbiome function in children: a randomized, double-blind, placebo-controlled trial

乳铁蛋白联合动物双歧杆菌乳亚种BB-12可改善儿童呼吸道感染并调节肠道菌群功能:一项随机、双盲、安慰剂对照试验

Shi, Zhe; Zhu, Huajiang; Tao, Xiaohan; Liu, Feitong; Zhao, Lingling; Zhang, Jiahui; Zhang, Jinping

Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation

在一项针对携带 KRAS G12C 突变的晚期实体瘤患者的 II 期临床试验中,KRAS G12C 抑制剂 Garsorasib 联合或不联合 EGFR 抗体西妥昔单抗,用于治疗结直肠癌患者。

Ruan, Dan-Yun; Wu, Hao-Xiang; Xu, Ye; Munster, Pamela N; Deng, Yanhong; Richardson, Gary; Yan, Dong; Lee, Myung-Ah; Lee, Keun-Wook; Pan, Hongming; Hager, Steven; Li, Xingya; Wei, Shaozhong; Hou, Xinfang; Underhill, Craig; Millward, Michael; Nordman, Ina; Zhang, Jingdong; Shan, Jianzhen; Han, Guohong; Grewal, Jaspreet; Gadgeel, Shirish M; Sanborn, Rachel E; Huh, Seok Jae; Hu, Xiaohua; Zhang, Yihong; Xiang, Ziyong; Luo, Laisheng; Xie, Xiaoxi; Shi, Zhe; Wang, Yaolin; Zhang, Ling; Wang, Feng; Xu, Rui-Hua

Oncolytic adenovirus delivery of neoantigens sensitizes low-mutation tumors to anti-PD-1 therapy and prevents metastasis.

利用溶瘤腺病毒递送新抗原可使低突变肿瘤对PD-1抑制剂疗法敏感,并防止转移。

Shen Ke-Yu, Yu Shi-Zhe, Su Ying-Han, Xie Sun-Zhe, Zhang Chen, Xu Hao, Yang SamI, Zou Tian-Tian, Fu Yan, Wang Hao, Fang Lin, Zheng Yan, Su Chang-Qing, Qin Lun-Xiu

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics.

利用高通量蛋白质组学对 cereblon 新底物景观进行无偏映射

Steger Martin, Nishiguchi Gisele, Wu Qiong, Schwalb Bjoern, Shashikadze Bachuki, McGowan Kevin, Actis Marisa, Aggarwal Anup, Shi Zhe, Price Jeanine, Mayasundari Anand, Yang Lei, Bednarz Anastasia H, Machata Sophie, Graef Tobias, Bartoschek Denis, Demichev Vadim, Ohmayer Uli, Yang Jun, Daub Henrik, Rankovic Zoran

Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity.

海马二肽基肽酶 9 双向调节与突触可塑性相关的记忆

Zhao Ya-Bo, Wang Shi-Zhe, Guo Wen-Ting, Wang Le, Tang Xun, Li Jin-Nan, Xu Lin, Zhou Qi-Xin

Rac1 in parvalbumin neurons of the medial prefrontal cortex governs rapid forgetting of social memory.

内侧前额叶皮层小白蛋白神经元中的 Rac1 控制着社会记忆的快速遗忘

Li Meng, Wang Shi-Zhe, Zhao Ya-Bo, Tang Xun, Xu Lin, Wang Hongsheng, Zhou Qi-Xin