日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of TCE-secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity.

CD3É› 纳米抗体工程化细胞外囊泡驱动体内生成分泌 TCE 的 CAR-T 细胞，用于实体瘤治疗，具有记忆反应和最小免疫原性。

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202519440
Huang Shi-Wei, Lin Yu-Chuan, Pan Chih-Ming, Chen Yeh, Shie Ming-You, Chen Cheng-Yu, Kan Kai-Wen, Chen Yi-Wen, Liu Ming-Chao, Wu Chung-Chun, Chiang Yu-Ting, Ho Huai-Ping, Lin Chen-Yu, Lin Pei-Ying, Huang Yu-Han, Rusli Steffany, Mao Wan-Yu, Huang Pei-Wen, Wang Sin-Ting, Tsai Wan-Chen, Chiu Ya-Hsu, Lin Ting-Hsun, Chiang Wan-Ling, Chang Che-Kai, Lai Zi-Lun, Chen Mei-Chih, Chiu Shao-Chih, Cho Der-Yang
细胞生物学
CD3
囊泡
发表日期：2026
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Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury

构建靶向整合素αvβ8的细胞外囊泡，以递送BDNF mRNA促进脊髓损伤后的运动功能恢复

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-026-04222-7
Shie, Ming-You; Chiu, Cheng-Di; Chen, Yeh; Lin, Yen-Hong; Yu, Min-Hua; Chiu, You-Pen; Chiu, Po-Fan; Chen, Cheng-Yu; Chen, Yi-Wen; Chen, Mei-Chih; Cho, Der-Yang
神经科学
脊髓损伤
BDNF
囊泡
细胞生物学
发表日期：2026
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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery.

构建靶向 HLA-G 的细胞外囊泡纳米平台，通过精准的癌症药物递送增强癌症治疗效果。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66451-y
Shie Ming-You, Huang Shi-Wei, Chen Yeh, Chen Mei-Chih, Pan Chih-Ming, Chen Cheng-Yu, Lin Yen-Hong, Yu Min-Hua, Kan Kai-Wen, Chiu Shao-Chih, Ho Hui-Chun, Chen Yi-Wen, Cho Der-Yang
细胞生物学
囊泡
发表日期：2025
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Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson's disease therapy

利用工程化细胞外囊泡介导的姜黄素递送系统，在大脑微环境中调节溶酶体、线粒体和小胶质细胞的重编程，从而治疗帕金森病。

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03911-z
Shie, Ming-You; Chen, Mei-Chih; Chen, Yeh; Huang, Shi-Wei; Lin, Yen-Hong; Yu, Min-Hua; Pan, Chih-Ming; Chen, Cheng-Yu; Chen, Yi-Wen; Hsieh, Ching-Liang; Chiu, Shao-Chih; Kao, Shung-Te; Lin, Jaung-Geng; Cho, Der-Yang
胶质细胞
帕金森
神经科学
线粒体
囊泡
细胞生物学
发表日期：2025
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Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration

锂掺杂硅酸钙支架激活M2极化巨噬细胞来源的富含miR-145-5p的细胞外囊泡，从而增强骨免疫调节，加速骨再生

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03679-2
Kuo, Ting-You; Lin, Tsung-Li; Lin, Yen-Hong; Chen, Cheng-Yu; Cho, Der-Yang; Chen, Yi-Wen; Shie, Ming-You
巨噬细胞
细胞生物学
囊泡
巨噬细胞
免疫/内分泌
发表日期：2025
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Osteoimmunomodulation of astragalus-calcium silicate scaffolds-activated M2 macrophage-derived miR-218-rich exosome for enhanced bone regeneration

黄芪-硅酸钙支架激活M2巨噬细胞来源的富含miR-218的外泌体，从而增强骨再生，发挥骨免疫调节作用

期刊:Materials Today Bio
影响因子:10.2
doi:10.1016/j.mtbio.2025.102286
Chen, Cheng-Yu; Lee, Jian-Jr; Lin, Yen-Hong; Kuo, Ting-You; Cho, Der-Yang; Shie, Ming-You
巨噬细胞
外泌体
细胞生物学
巨噬细胞
免疫/内分泌
发表日期：2025
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Mitochondrial biogenesis modulation by silicon-stimulated mesenchymal stem cells-derived extracellular vesicles drives angio- and lymphangiogenesis in chronic wound healing.

硅刺激间充质干细胞衍生的细胞外囊泡调节线粒体生物合成，从而驱动慢性伤口愈合中的血管生成和淋巴管生成。

期刊:Materials Today Bio
影响因子:10.2
doi:10.1016/j.mtbio.2025.102629
Yu Min-Hua, Lin Yen-Hong, Liu En-Wei, Hsu-Jiang Tai-Yi, Cho Der-Yang, Lee Jian-Jr, Shie Ming-You
发育与干细胞
干细胞
Angiogenesis
线粒体
血管生成
囊泡
发表日期：2025
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Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration

锂掺杂硅酸钙水泥调节免疫微环境，促进M2型巨噬细胞极化，从而增强骨再生。

期刊:Journal of Biological Engineering
影响因子:6.5
doi:10.1186/s13036-024-00467-8
Lin, Yen-Hong; Chen, Cheng-Yu; Chen, Kun-Hao; Kuo, Ting-You; Lin, Tsung-Li; Shie, Ming-You
巨噬细胞
巨噬细胞
细胞生物学
免疫/内分泌
发表日期：2025
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Preliminary study of utilizing a patient derived tumor spheroid model to augment precision therapy in metastatic brain tumors

利用患者来源的肿瘤球体模型增强转移性脑肿瘤精准治疗的初步研究

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-024-83409-0
Chang, Chun-Jen; Kan, Kai-Wen; Shih, Yu-Yin; Nan, Yu-Han; Juan, Yu-Chung; Tu, Chih-Hsiu; Yang, Chen-Ting; Hsu, Wei-Lin; Cho, Der-Yang; Shie, Ming-You; Chen, Yi-Wen; Chen, Chun-Chung
肿瘤
肿瘤免疫
神经科学
发表日期：2024
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Fabrication of 3D Printed Poly(lactic acid)/Polycaprolactone Scaffolds Using TGF-β1 for Promoting Bone Regeneration.

利用TGF-β1促进骨再生的3D打印聚乳酸/聚己内酯支架的制备

期刊:Polymers
影响因子:4.9
doi:10.3390/polym13213731
Cheng Cheng-Hsin, Shie Ming-You, Lai Yi-Hui, Foo Ning-Ping, Lee Mon-Juan, Yao Chun-Hsu
骨科研究
TGF-β
发表日期：2021
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